Kawahara, Norio et al. published their research in Heterocycles in 1981 | CAS: 5676-58-4

2,5-Dimethylbenzoxazole (cas: 5676-58-4) belongs to benzoxazole derivatives. Its aromaticity makes it relatively stable, although as a heterocycle, it has reactive sites which allow for functionalization. Due to its versatile biological properties, benzoxazole has been incorporated as an essential pharmacophore and substructure in many medicinal compounds.Reference of 5676-58-4

Some novel reactions of benzoxazole derivatives with dimethyl acetylenedicarboxylate. II was written by Kawahara, Norio;Katsuyama, Michiko;Itoh, Tsuneo;Ogura, Haruo. And the article was included in Heterocycles in 1981.Reference of 5676-58-4 This article mentions the following:

Reaction of 2-alkylbenzoxazoles I (R, R1 = H, H; Me, H; Me, Me) with R2CCR2 (R2 = CO2Me) in EtOH or CMe3OH at room temperature gave tricyclic compound II, hydration product III (R3 = H), solvent adduct III (R3 = CMe3), and ring-opened compounds RC6H3(O2CCH2R1)NHCR2:CHR2-4,3 and RC6H3(OH)[N(COCH2R1)CR2:CHR2]-4,3 (IV). IV was a main product of photochem. reaction of I with R2CCR2. In the experiment, the researchers used many compounds, for example, 2,5-Dimethylbenzoxazole (cas: 5676-58-4Reference of 5676-58-4).

2,5-Dimethylbenzoxazole (cas: 5676-58-4) belongs to benzoxazole derivatives. Its aromaticity makes it relatively stable, although as a heterocycle, it has reactive sites which allow for functionalization. Due to its versatile biological properties, benzoxazole has been incorporated as an essential pharmacophore and substructure in many medicinal compounds.Reference of 5676-58-4

Referemce:
Benzoxazole – Wikipedia,
Benzoxazole | C7H5NO – PubChem