1-Bromo-4-(S-methylsulfonimidoyl)benzene (BD336512) is a building block containing a sulfoximine group. Several CDK and ATR inhibitors have exemplified the utilization of the NH sulfoximine group as abioisostere for a sulfonamide group to overcome the main project hurdles of aqueous solubility, sulfonamide-mediated off-target activity and IP. Moreover, its NH group could be expediently further functionalized through Buchwald-Hartwig coupling reaction and multifarious nucleophilic reactions.. Recommended Products is: 4381-25-3 and 83730-53-4.
A tetrabutylammonium tribromide-mediated three-component reaction of alkenes, diselenides, and sulfoximines was established herein, providing direct and metal-free access to diverse ¦Â-arylseleno sulfoximine derivatives I [R1 = Ph, 4-MeC6H4, 4-FC6H4, etc.; R2 = Ph, 4-FC6H4, 2-MeC6H4, etc.; R3 = Me, Et, cyclopropyl; R4 = Et, Ph, 4-BrC6H4, etc.]. This regioselective sulfoximido-selenization protocol proceeds efficiently under mild and ambient conditions with generally good yields. This strategy was featured by step and atom economy, practicability, a broad substrate scope, and gram-scale synthesis.
Synthesis of ¦Â-Arylseleno Sulfoximines: A Metal-Free Three-Component Reaction Mediated by Tetrabutylammonium Tribromide. Recommended basis is Sulfoximine, Bioisosteric. Products is: https://www.ambeed.com/products/1621962-30-8.html, 50578-18-2
Referemce:
Benzoxazole – Wikipedia,
Benzoxazole | C7H5NO – PubChem