Multicatalytic Beckmann rearrangement of 2-hydroxylarylketone oxime: Switchable synthesis of benzo[d]oxazoles and N-(2-hydroxylaryl)amides was written by Li, Zhen;Fang, Chengtao;Zheng, Yannan;Qiu, Guanyinsheng;Li, Xiaofang;Zhou, Hongwei. And the article was included in Tetrahedron Letters in 2018.Application of 5676-58-4 This article mentions the following:
A switchable synthesis route was developed for benzo[d]oxazole derivatives and (2-hydroxylaryl)benzamide from 2-hydroxylbenzeneketoxime using organomols. (BOP-Cl, and CNC) and Lewis acid cocatalyzed Beckmann rearrangement (BR) reaction. Further, this reaction was switched using different organocatalysts. In the experiment, the researchers used many compounds, for example, 2,5-Dimethylbenzoxazole (cas: 5676-58-4Application of 5676-58-4).
2,5-Dimethylbenzoxazole (cas: 5676-58-4) belongs to benzoxazole derivatives. Its aromaticity makes it relatively stable, although as a heterocycle, it has reactive sites which allow for functionalization. The wide range in therapeutic potential of benzoxazole derivatives is related to the favourable interactions of the benzoxazole moiety with different protein targets.Application of 5676-58-4
Referemce:
Benzoxazole – Wikipedia,
Benzoxazole | C7H5NO – PubChem