Most of the natural products isolated at present are heterocyclic compounds, so heterocyclic compounds occupy an important position in the research of organic chemistry. A compound: 96651-85-3, is researched, SMILESS is Cl.C1CC2(CCNCC2)C2=CC=CC=C12, Molecular C13H18ClNJournal, Bioorganic & Medicinal Chemistry Letters called Peptidomimetic growth hormone secretagogues: synthesis and biological activities of analogs varied at the indole nucleus of the prototypical spiropiperidine L-162,752, Author is Nargund, Ravi P.; Chen, Meng-Hsin; Johnston, David B. R.; Barakat, Khaled J.; Tata, James R.; Cheng, Kang; Jacks, Thomas M.; Chan, Wanda W.-S.; Wei, Liente, the main research direction is spiropiperidine preparation growth hormone secretagogue; structure activity spiropiperidine growth hormone secretagogue; L 162752 analog growth hormone secretagogue.Product Details of 96651-85-3.
SAR studies around the indole nucleus of the prototypical peptidomimetic L-162,752 (I; R = 3-indolyl) revealed that the D-Trp residue could be replaced with 3-phenylpropyl-D-glycine and O-benzyl-D-serine to provide secretagogues I (R = PhCH2CH2, PhCH2O) with comparable intrinsic activity but with significantly better and oral activity in dogs. Use of dimethyl-β-alanine amino side chains led to considerable loss of activity in the D-homophenylalanine and O-benzyl-D-serine series II [R = PhCH2CH2, PhCH2O; R1 = H. CH2CH(OH)Me, CH2CH(OH)CH2OH] .
The article 《Peptidomimetic growth hormone secretagogues: synthesis and biological activities of analogs varied at the indole nucleus of the prototypical spiropiperidine L-162,752》 also mentions many details about this compound(96651-85-3)Product Details of 96651-85-3, you can pay attention to it, because details determine success or failure
Reference:
Benzoxazole – Wikipedia,
Benzoxazole | C7H5NO – PubChem