Facile synthesis of 3-arylpyridine derivatives by palladacycle-catalyzed Stille cross-coupling reaction was written by Ma, Gaizhi;Leng, Yuting;Wu, Yusheng;Wu, Yangjie. And the article was included in Tetrahedron in 2013.Electric Literature of C13H8BrNO This article mentions the following:
The Stille cross-coupling reaction of a variety of aryl halides (X = Cl, Br, I) with 3- or 2-(trialkylstannyl)pyridines was catalyzed by cyclopalladated ferrocenylimine. This reaction allows formation of arylpyridine derivatives in moderate to excellent yields. Functional groups on the aryl halides, such as amino, hydroxyl, keto, and formyl, are tolerated and the reactions with arylbenzoxazole substrates also proceeded well. In the experiment, the researchers used many compounds, for example, 2-(3-Bromophenyl)benzo[d]oxazole (cas: 99586-31-9Electric Literature of C13H8BrNO).
2-(3-Bromophenyl)benzo[d]oxazole (cas: 99586-31-9) belongs to benzoxazole derivatives. Its aromaticity makes it relatively stable, although as a heterocycle, it has reactive sites which allow for functionalization. Benzoxazoles are prominent in medicinal chemistry due to their wide spectrum of pharmacological activities such as anti-inflammatory, antimycobacterial, antihistamine.Electric Literature of C13H8BrNO
Referemce:
Benzoxazole – Wikipedia,
Benzoxazole | C7H5NO – PubChem