Mitra, Raja; Samuelson, Ashoka G. published the artcile< Substitution-Modulated Anticancer Activity of Half-Sandwich Ruthenium(II) Complexes with Heterocyclic Ancillary Ligands>, Application In Synthesis of 13451-78-0, the main research area is crystal mol structure cymeneruthenium mercaptobenzoxazole mercaptobenzothiazole mercaptobenzimidazole preparation anticancer.
Ten new organometallic half-sandwich Ru complexes with heterocyclic ligands were synthesized. The substituents on the ancillary heterocyclic ligands were varied to understand the effect of substitution on anticancer activity. The crystallog. characterization of five complexes confirms that they adopt three-legged piano-stool structures and are stabilized by intramol. H bonding. The two complexes with chloro- and bromo-substituted mercaptobenzothiazole ligands exhibit halogen bonding in the solid state. In aqueous media, the complexes form dinuclear Ru species. The complex with the noncytotoxic heterocycle, 6-fluoro-2-mercaptobenzothiazole, and the complex with the unsubstituted 2-mercaptobenzothiazole are the most active against A2780 and KB cell lines. The substitution of the H atoms on the ancillary ligand with Cl or Br atoms decreases the anticancer activity. With the exception of the F-substituted mercaptobenzoxazole ligand, the complexes with mercaptobenzoxazole ligands are inactive against all of the tested cell lines. Ru complexes with mercaptonaphthimidazole and mercaptobenzimidazole do not show any anticancer activity. The active complexes show a biphasic melting curve when incubated with calf thymus (CT) DNA. These complexes only inhibit thioredoxin reductase (TrxR) enzyme activity to a small extent. The substitution of H atoms with F atoms in the aromatic heterocyclic ligands on the organometallic half-sandwich Ru complexes has the most beneficial effect on their anticancer activity.
European Journal of Inorganic Chemistry published new progress about Antitumor agents. 13451-78-0 belongs to class benzoxazole, and the molecular formula is C7H4FNOS, Application In Synthesis of 13451-78-0.
Referemce:
Benzoxazole – Wikipedia,
Benzoxazole | C7H5NO – PubChem