1-Bromo-4-(S-methylsulfonimidoyl)benzene (BD336512) is a building block containing a sulfoximine group. Several CDK and ATR inhibitors have exemplified the utilization of the NH sulfoximine group as abioisostere for a sulfonamide group to overcome the main project hurdles of aqueous solubility, sulfonamide-mediated off-target activity and IP. Moreover, its NH group could be expediently further functionalized through Buchwald-Hartwig coupling reaction and multifarious nucleophilic reactions.. Recommended Products is: 4381-25-3 and 83730-53-4.
A simple and mild copper salt-catalyzed N-arylation of sulfoximines in high yields is reported. Cu(OAc)2 activated arylboronic acids for the reaction with NH-sulfoximines without addnl. base or heating. Furthermore, this method allowed the preparation of N-arylated sulfoximines, which have previously been more difficult to access.
Cu(OAc)2-catalyzed N-arylations of sulfoximines with aryl boronic acids. Recommended basis is Sulfoximine, Bioisosteric. Products is: https://www.ambeed.com/products/1621962-30-8.html, 50578-18-2
Referemce:
Benzoxazole – Wikipedia,
Benzoxazole | C7H5NO – PubChem