In heterogeneous catalysis, the catalyst is in a different phase from the reactants. name: 2-Oxo-2,3-dihydrobenzo[d]oxazole-6-carboxylic acid, At least one of the reactants interacts with the solid surface in a physical process called adsorption in such a way. 54903-16-1, name is 2-Oxo-2,3-dihydrobenzo[d]oxazole-6-carboxylic acid. In an article£¬Which mentioned a new discovery about 54903-16-1
New antimitotic agents with activity in multi-drug-resistant cell lines and in vivo efficacy in murine tumor models
During a screen for compounds that could inhibit cell proliferation, a series of new tubulin-binding compounds was identified with the discovery of oxadiazoline 1 (A-105972). This compound showed good cytotoxic activity against non-multi-drug-resistant and multi-drug-resistant cancer cell lines, but its utility in vivo was limited by a short half-life. Medicinal chemistry efforts led to the discovery of indolyloxazoline 22g (A-259745), which maintained all of the in vitro activity seen with oxadiazoline 1, but also demonstrated a better pharmacokinetic profile, and dose-dependent in vivo activity. Over a 28 day study, indolyloxazoline 22g increased the life span of tumor-implanted mice by up to a factor of 3 upon oral dosing. This compound, and others of its structural class, may prove to be useful in the development of new chemotherapeutic agents to treat human cancers.
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Reference£º
Benzoxazole – Wikipedia,
Benzoxazole | C7H5NO – PubChem