Chemistry is an experimental science, and the best way to enjoy it and learn about it is performing experiments. category: benzoxazole. Introducing a new discovery about 3889-13-2, Name is 5-Nitro-2,3-dihydro-1,3-benzoxazol-2-one
2,4-Diaminopyrimidine inhibitors of c-Met kinase bearing benzoxazepine anilines
Elaboration of the SAR around a series of 2,4-diaminopyrimidines led to a number of c-Met inhibitors in which kinase selectivity was modulated by substituents appended on the C4-aminobenzamide ring and the nature of the C2-aminoaryl ring. Further lead optimization of the C2-aminoaryl group led to benzoxazepine analogs whose pharmaceutical properties were modulated by the nature of the substituent on the benzoxazepine nitrogen. Tumor stasis (with partial regressions) were observed when an orally bioavailable analog was evaluated in a GTL-16 tumor xenograft mouse model. Subsequent PK/PD studies suggested that a metabolite contributed to the overall in vivo response.
Note that a catalyst decreases the activation energy for both the forward and the reverse reactions and hence accelerates both the forward and the reverse reactions.category: benzoxazole, you can also check out more blogs about3889-13-2
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Benzoxazole – Wikipedia,
Benzoxazole | C7H5NO – PubChem