Chemistry, like all the natural sciences, begins with the direct observation of nature¡ª in this case, of matter.392-56-3, Name is Hexafluorobenzene, SMILES is FC1=C(F)C(F)=C(F)C(F)=C1F, belongs to benzoxazole compound. In a document, author is Garrido, Amanda, introduce the new discover, Safety of Hexafluorobenzene.
Direct Access to Highly Functionalised Benzimidazoles and Benzoxazoles from a Common Precursor
Benzoxazole and benzimidazole are commonly encountered heterocycles in medicinal chemistry and their functionalisation around 1-, 2-, 5-, and/or 6-positions provides a wide range of molecules of biological interest. In this manuscript, a straightforward preparation of diversely and highly substituted benzimidazoles and benzoxazoles on these positions, from a common starting material, a 3,3-dibromoacrolein, is described. Such acrolein derivatives are almost never described in the literature or used as ‘building-block’ for organic synthesis. The double electrophilicity of this substrate was found to be advantageous for condensation with two equivalents of various 1,2-diaminobenzene or 2-aminophenol derivatives. This one-pot reaction performed under metal-free and mild conditions allows the creation of three new carbon-heteroatom bonds and affords the desired heterocycles.
The proportionality constant is the rate constant for the particular unimolecular reaction. the reaction rate is directly proportional to the concentration of the reactant. I hope my blog about 392-56-3 is helpful to your research. Safety of Hexafluorobenzene.
Reference:
Benzoxazole – Wikipedia,
,Benzoxazole | C7H5NO – PubChem