Reference of 72752-81-9, A catalyst don’t appear in the overall stoichiometry of the reaction it catalyzes, but it must appear in at least one of the elementary reactions in the mechanism for the catalyzed reaction. 72752-81-9, Name is Methyl 2-mercaptobenzo[d]oxazole-6-carboxylate, molecular formula is C9H7NO3S. In a Article£¬once mentioned of 72752-81-9
Design, synthesis and pharmacology of aortic-selective acyl-CoA: Cholesterol O-acyltransferase (ACAT/SOAT) inhibitors
We describe our molecular design of aortic-selective acyl-coenzyme A:cholesterol O-acyltransferase (ACAT, also abbreviated as SOAT) inhibitors, their structure?activity relationships (SARs) and their pharmacokinetic (PK) and pharmacological profiles. The connection of two weak ligands?N-(2,6-diisopropylphenyl)acetamide (50% inhibitory concentration [IC50] = 8.6 muM) and 2-(methylthio)benzo[d]oxazole (IC50 = 31 muM)?via a linker comprising a 6 methylene group chains yielded a highly potent molecule, 9-(benzo[d]oxazol-2-ylthio)-N-(2,6-diisopropylphenyl)nonanamide (3h) that exhibited high potency (IC50 = 0.004 muM) toward aortic ACAT. This head-to-tail design made it possible to markedly enhance the activity to 2150- to 7750-fold and to discriminate the isoform-selectivity based on the double-induced fit mechanism. At doses of 1 and 3 mg/kg, 3h significantly decreased the lipid-accumulation areas in the aortic arch to 74 and 69%, respectively without reducing the plasma total cholesterol level in high fat- and cholesterol-fed F1B hamsters. Here, we demonstrate the antiatherosclerotic effect of 3h in vivo via its direct action on aortic ACAT and its powerful modulator of cholesterol level. This molecule is a potential therapeutic agent for the treatment of diseases involving ACAT-1 overexpression.
Balanced chemical reaction does not necessarily reveal either the individual elementary reactions by which a reaction occurs or its rate law.Reference of 72752-81-9. In my other articles, you can also check out more blogs about 72752-81-9
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Benzoxazole – Wikipedia,
Benzoxazole | C7H5NO – PubChem