Moure, Abraham L.; Narula, Gagandeep; Sorrentino, Flavia; Bojang, Adama; Tsui, Clement K. M.; Sao Emani, Carine; Porras-De Francisco, Esther; Diaz, Beatriz; Rebollo-Lopez, Maria Jose; Torres-Gomez, Pedro Alfonso; Lopez-Roman, Eva Maria; Camino, Isabel; Casado Castro, Patricia; Guijarro Lopez, Laura; Ortega, Fatima; Ballell, Lluis; Barros-Aguirre, David; Remuinan Blanco, Modesto; Av-Gay, Yossef published the artcile< MymA Bioactivated Thioalkylbenzoxazole Prodrug Family Active against Mycobacterium tuberculosis>, Formula: C7H4FNOS, the main research area is Mycobacterium tuberculosis prodrug MymA intracellular bacteria solubility permeability stability.
Screening of a GSK-proprietary library against intracellular Mycobacterium tuberculosis identified 1, a thioalkylbenzoxazole hit. Biol. profiling and mutant anal. revealed that this compound is a prodrug that is bioactivated by the mycobacterial enzyme MymA. A hit-expansion program including design, synthesis, and profiling of a defined set of analogs with optimized drug-like properties led to the identification of an emerging lead compound, displaying potency against intracellular bacteria in the low micromolar range, high in vitro solubility and permeability, and excellent microsomal stability.
Journal of Medicinal Chemistry published new progress about Antibacterial agents. 13451-78-0 belongs to class benzoxazole, and the molecular formula is C7H4FNOS, Formula: C7H4FNOS.
Referemce:
Benzoxazole – Wikipedia,
Benzoxazole | C7H5NO – PubChem