Synthesis of benzoxazoles by an efficient Ullmann-type intramolecular C(aryl)-O bond-forming coupling cyclization with a BINAM-copper(II) catalyst was written by Naidu, Ajay B.;Sekar, Govindasamy. And the article was included in Synthesis in 2010.Formula: C13H8BrNO This article mentions the following:
A wide range of 2-arylbenzoxazoles were synthesized from the corresponding N-(2-iodophenyl)benzamides through intramol. C(aryl)-O bond formation via Ullmann-type coupling cyclization in the presence of a catalytic amount of an easily available BINAM-copper(II) complex under very mild reaction conditions (82 °C). Less reactive bromo and chloro analogs of the N-(2-halophenyl)benzamides were also successfully cyclized to produce benzoxazoles, without increasing the catalyst loading. In the experiment, the researchers used many compounds, for example, 2-(3-Bromophenyl)benzo[d]oxazole (cas: 99586-31-9Formula: C13H8BrNO).
2-(3-Bromophenyl)benzo[d]oxazole (cas: 99586-31-9) belongs to benzoxazole derivatives. Benzoxazole derivatives have gained a lot of importance in the past few years because of their use in intermediates for the preparation of new biological materials. It is found within the chemical structures of pharmaceutical drugs such as flunoxaprofen and tafamidis.Formula: C13H8BrNO
Referemce:
Benzoxazole – Wikipedia,
Benzoxazole | C7H5NO – PubChem