New research progress on 392-56-3 in 2021.Enzyme inhibitors cause a decrease in the reaction rate of an enzyme-catalyzed reaction by binding to a specific portion of an enzyme and thus slowing or preventing a reaction from occurring. 392-56-3, Name is Hexafluorobenzene, molecular formula is , belongs to benzoxazole compound. In a document, author is Wang, Mei-Yan, Safety of Hexafluorobenzene.
alpha-Glucosidase is known to catalyze the digestion of carbohydrates and release free glucose into the digestive tract. Protein tyrosine phosphatase 1B (PTP1B) is engaged in the dephosphorylation of the insulin receptor and regulation of insulin sensitivity. Therefore, dual antagonists by targeting both -glucosidase and PTP1B may be potential candidates for type 2 diabetes therapy. In this work, three series of novel N-aryl–(benzoazol-2-yl)-sulfanylalkanamides were synthesized and assayed for their -glucosidase and PTP1B inhibitory activities, respectively. Compound 3l, exhibiting the most effective -glucosidase inhibitory activity (IC50=10.96m (3l), IC50=51.32m (Acarbose), IC50=18.22m (Ursolic acid)) and potent PTP1B inhibitory activity (IC50=13.46m (3l), IC50=14.50m (Ursolic acid)), was identified as a novel dual inhibitor of -glucosidase and PTP1B. Furthermore, 3l is a highly selective PTP1B inhibitor because no inhibition was showed by 3l at 100m against PTP-MEG2, TCPTP, SHP2, or SHP1. Subsequent kinetic analysis revealed 3l inhibited -glucosidase in a reversible and mixed manner. Molecular docking study indicated that hydrogen bonds, van der Waals, charge interactions and Pi-cation interactions all contributed to affinity between 3l and -glucosidase/PTP1B.
We’ll also look at important developments in the pharmaceutical industry because understanding organic chemistry is important in understanding health, medicine, 392-56-3. The above is the message from the blog manager. Safety of Hexafluorobenzene.
Reference:
Benzoxazole – Wikipedia,
,Benzoxazole | C7H5NO – PubChem