Heterocyclic compounds can be divided into two categories: alicyclic heterocycles and aromatic heterocycles. Compounds whose heterocycles in the molecular skeleton cannot reflect aromaticity are called alicyclic heterocyclic compounds. Compound: 96651-85-3, is researched, Molecular C13H18ClN, about Spirovesamicols: Conformationally Restricted Analogs of 2-(4-Phenylpiperidino)cyclohexanol (Vesamicol, AH5183) as Potential Modulators of Presynaptic Cholinergic Function, the main research direction is spirovesamicol preparation vesamicol receptor ligand structure; cholinergic neurotransmission spirovesamicol vesamicol receptor ligand.SDS of cas: 96651-85-3.
In an effort to develop selective inhibitors of vesicular acetylcholine storage, the authors have synthesized a series of semirigid vesamicol receptor ligands based on the structure of 2-(4-phenylpiperidino)cyclohexanol (vesamicol, AH5183). In these compounds, the planes of the Ph and piperidyl moieties of the parent ligand vesamicol are held at right angles by vinyl, ethylene, and propylene bridges to form N-substituted derivatives of spiro[indene-1,4′-piperidine], 2,3-dihydrospiro[indene-1,4′-piperidine], and 3,4-dihydrospiro[naphthalene-1(2H),4′-piperidine], resp. Preliminary evaluation of these compounds in elec. organ synaptic vesicles revealed several potent vesamicol receptor ligands, such as1′-(2-hydroxy-1,2,3,4-tetrahydronaphth-3-yl)spiro[1H-indene-1,4′-piperidine] and 1′-(2-hydroxy-1,2,3,4-tetrahydronaphth-3-yl)spiro[2-bromo-1H-indene-1,4′-piperidine], which display subnanomolar affinity for this receptor. In general, the vinyl and ethylene bridges yielded the most potent analogs while the propylene-bridged analogs were among the least potent compounds The increased rigidity of these spiro-fused compounds, relative to the corresponding simple 4-phenylpiperidine derivatives of vesamicol, is expected to confer greater selectivity for the vesamicol receptor.
This compound(2,3-Dihydrospiro[indene-1,4′-piperidine] hydrochloride)SDS of cas: 96651-85-3 was discussed at the molecular level, the effects of temperature and reaction time on the properties of the compound were discussed, and the optimum reaction conditions were selected.
Reference:
Benzoxazole – Wikipedia,
Benzoxazole | C7H5NO – PubChem