One of the major reasons for studying chemical kinetics is to use measurements of the macroscopic properties of a system, such as the rate of change in the concentration of reactants or products with time. 367-11-3, Name is 1,2-Difluorobenzene, formurla is C6H4F2. In a document, author is Li, Zhengyu, introducing its new discovery. Safety of 1,2-Difluorobenzene.
One-Pot Synthesis of 3-Difluoromethyl Benzoxazole-2-thiones
A one-pot strategy for the diversified synthesis of 3-difluoromethyl benzoxazole-2-thiones is reported. The reaction of 2-aminophenol, sodium chlorodifluoroacetate, and elemental sulfur in the presence of NaOt-Bu gives exclusively 3-difluoromethyl benzoxazole-2-thiones in good yield (up to 98%). The mechanism of this reaction presumably involves first cyclization of 2-aminophenols with thiocarbonyl fluoride, followed by N-difluoromethylation with difluorocarbene. The developed synthetic procedures are versatile, robust, and easily scalable for the synthesis of 3-difluoromethyl benzoxazole-2-thione derivatives, some of which have shown insecticidal activities.
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Reference:
Benzoxazole – Wikipedia,
,Benzoxazole | C7H5NO – PubChem