New Advances in Chemical Research in 2021. In heterogeneous catalysis, catalysts provide a surface to which reactants bind in a process of adsorption. The reactant in an enzyme-catalyzed reaction is called a substrate. 5471-63-6, Name is 1,3-Diphenylisobenzofuran, molecular formula is , belongs to benzoxazole compound. In a document, author is Yuan, Xu, Name: 1,3-Diphenylisobenzofuran.
Herein, we have carried out a structural optimization campaign to discover the novel anti-tumor agents with our previously screened YQY-26 as the hit compound. A library of thirty-seven 6-amide-2-aryl benzoxazole/benzimidazole derivatives has been designed and synthesized based on the highly conserved active site of VEGFR-2. Several title compounds exhibited selective inhibitory activities against VEGFR-2 than EGFR kinases, which also displayed selective anti-proliferation potency against the HUVEC and HepG2 than the A549 and MDA-MB-231 cancer cell lines. The newly synthesized compounds were evaluated for anti-angiogenesis capability by chick chorioallantoic membrane (CAM) assay. Among them, compounds 9d showed the most potent anti-angiogenesis ability (79% inhibition at 10 nM/eggs), the efficient cytotoxic activities (in vitro against the HUVEC and HepG2 cell lines with IC50 values of 1.47 and 2.57 mu M, respectively), and excellent VEGFR-2 kinase inhibition (IC50 = 0.051 mu M). The molecular docking analysis revealed that compound 9d is a Type 11 inhibitor of VEGFR-2 kinase. These results indicated that the 6-amide-2-arylbenzoxazole and 6-amide-2-aryl benzimidazole derivatives are promising inhibitors of VEGFR-2 kinase for the potential treatment of anti-angiogenesis. (C) 2019 Elsevier Masson SAS. All rights reserved.
Balanced chemical reaction does not necessarily reveal either the individual elementary reactions by which a reaction occurs or its rate law. In my other articles, you can also check out more blogs about 5471-63-6. Name: 1,3-Diphenylisobenzofuran.
Reference:
Benzoxazole – Wikipedia,
,Benzoxazole | C7H5NO – PubChem