5-Fluorobenzo[d]oxazole-2-thiol, cas is 13451-78-0, it is a common heterocyclic compound, the benzoxazole compound, its synthesis route is as follows.,13451-78-0
Step 2 The 2-mercapto-5-fluorobenzoxazole (2.0 g, 11.8 mmol) is slurried into POCl3 (9.7 mL, 104 mmol). The slurry is treated with PCl5 (3.0 g, 14.2 mmol) and 5.0 mL of anhydrous CH2 Cl2. The mixture is stirred at room temperature for 5.5 hours. After this time excess POCl3 is removed under reduced pressure. The residue is treated with saturated aqueous NaHCO3 and the mixture is poured into a separatory funnel. The mixture is extracted with EtOAc and the combined extracts are washed with brine and dried over anhydrous Na2 SO4. Filtration and concentration gives 1.76 g of 2-chloro-5-fluorobenzoxazole as a waxy solid. The crude chloride is used in the piperazine displacement reaction.
With the rapid development of chemical substances, we look forward to future research findings about 5-Fluorobenzo[d]oxazole-2-thiol
Reference£º
Patent; Pharmacia & Upjohn Company; US5736545; (1998); A;,
Benzoxazole – Wikipedia
Benzoxazole | C7H5NO – PubChem