New learning discoveries about 13451-78-0

13451-78-0, In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles.,13451-78-0 ,5-Fluorobenzo[d]oxazole-2-thiol, other downstream synthetic routes, hurry up and to see

Name is 5-Fluorobenzo[d]oxazole-2-thiol, as a common heterocyclic compound, it belongs to benzoxazole compound, and cas is 13451-78-0, its synthesis route is as follows.

Step 2 The 2-mercapto-5-fluorobenzoxazole (2.0 g, 11.8 mmol) is slurried into POCl3 (9.7 mL, 104 mmol). The slurry is treated with PCl5 (3.0 g, 14.2 mmol) and 5.0 mL of anhydrous CH2 Cl2. The mixture is stirred at room temperature for 5.5 hours. After this time excess POCl3 is removed under reduced pressure. The residue is treated with saturated aqueous NaHCO3 and the mixture is poured into a separatory funnel. The mixture is extracted with EtOAc and the combined extracts are washed with brine and dried over anhydrous Na2 SO4. Filtration and concentration gives 1.76 g of 2-chloro-5-fluorobenzoxazole as a waxy solid. The crude chloride is used in the piperazine displacement reaction.

13451-78-0, In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles.,13451-78-0 ,5-Fluorobenzo[d]oxazole-2-thiol, other downstream synthetic routes, hurry up and to see

Reference:
Patent; Pharmacia & Upjohn Company; US5736545; (1998); A;,
Benzoxazole – Wikipedia
Benzoxazole | C7H5NO – PubChem