13673-62-6, In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 2-(Methylthio)benzo[d]oxazole, cas is 13673-62-6,the benzoxazole compound, it is a common compound, a new synthetic route is introduced below.
In order to prepare intermediate c-3, chlorosulfonic acid (3890 g; 33.3 mol) was stirred under nitrogen. Then intermediate c-2 (1288 g; 7.80 mol) was added portionwise maintaining the internal temperature below 60C by external cooling. After complete addition of intermediate b-2 the reaction mixture was stirred overnight at 85C. The heating was removed and the reaction mixture was cooled down until 65C. SOC12 was added dropwise while maintaining a controlled release of gases by good stirring. This mixture was stirred overnight at 65C. This reaction mixture was added to a well stirred mixture of EtOAc (6.9 kg) and ice (9.2kg) while maintained the temperature below 0C. The organic layer was isolated. The aqueous phase was extracted with EtOAc (3.1 KG). The combined organic layer was washed with 7.5 % NAHC03 (210 g/2.8 L water). Because the pH of this water layer was still 1, therefore another 125 g NAHC03 was added. This mixture was stirred for 1 hour, then the phases were separated. The organic layer was dried with NA2C03 (2.5 kg). After filtration 1935 g of intermediate c-3 was obtained (yield 94%, HPLC purity 94%) and used in the preparation of compound c-6.
Chemical properties determine the actual use. Each compound has specific chemical properties and uses. We look forward to more synthetic routes in the future to expand reaction routes of 2-(Methylthio)benzo[d]oxazole, 13673-62-6
Reference：
Patent; TIBOTEC PHARMACEUTICALS LTD.; WO2005/30739; (2005); A1;,
Benzoxazole – Wikipedia
Benzoxazole | C7H5NO – PubChem