Chemistry, like all the natural sciences, begins with the direct observation of nature¡ª in this case, of matter.92-86-4, Name is 4,4′-Dibromobiphenyl, SMILES is BrC1=CC=C(C2=CC=C(Br)C=C2)C=C1, belongs to benzoxazole compound. In a document, author is Jackson, Abigail C., introduce the new discover, Name: 4,4′-Dibromobiphenyl.
Benzimidazole and Benzoxazole Zinc Chelators as Inhibitors of Metallo-beta-Lactamase NDM-1
Bacterial expression of beta-lactamases, which hydrolyze beta-lactam antibiotics, contributes to the growing threat of antibacterial drug resistance. Metallo-beta-lactamases, such as NDM-1, use catalytic zinc ions in their active sites and hydrolyze nearly all clinically available beta-lactam antibiotics. Inhibitors of metallo-beta-lactamases are urgently needed to overcome this resistance mechanism. Zinc-binding compounds are promising leads for inhibitor development, as many NDM-1 inhibitors contain zinc-binding pharmacophores. Here, we evaluated 13 chelating agents containing benzimidazole and benzoxazole scaffolds as NDM-1 inhibitors. Six of the compounds showed potent inhibitory activity with IC50 values as low as 0.38 mu M, and several compounds restored the meropenem susceptibility of NDM-1-expressing E. coli. Spectroscopic and docking studies suggest ternary complex formation as the mechanism of inhibition, making these compounds promising for development as NDM-1 inhibitors.
The proportionality constant is the rate constant for the particular unimolecular reaction. the reaction rate is directly proportional to the concentration of the reactant. I hope my blog about 92-86-4 is helpful to your research. Name: 4,4′-Dibromobiphenyl.
Reference:
Benzoxazole – Wikipedia,
,Benzoxazole | C7H5NO – PubChem