4570-41-6, Benzo[d]oxazol-2-amine is a benzoxazole compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated,4570-41-6
General procedure: To a solution of carboxylic acid 3 in 3 mL dimethylformamide,were added trimethylamine (3 equiv), EDCI (1.2 equiv) and HOBt( 1.2 equiv) under ice-bath. After stirring at room temperature for30 min, amines (1 equiv) were added and the resulting mixture stirred for 24 h at room temperature. Reaction was detected byTLC (EtOAc/Hex 2:1). After completion of reaction, the mixture was diluted with water and extracted with ethyl acetate. The combined organic layers were washed by brine, dried over MgSO4 and concentrated. The crude product was further purified by silica gel chromatography eluted with EtOAc/Hex 2:1 to afford pure desired compound. 4.1.3.8 N-(Benzoxazol-2-yl)-5-(4-(4-chlorophenyl)piperazin-1-yl)pentanamide (4h¡¤HCl) The compound 4h was prepared from 3c and 2-aminobenzoxazole as a colorless solid (yield: 24.7percent). The free base was further converted into 4h¡¤HCl as a white solid. Mp: 78-79 ¡ãC. 1H NMR (300 MHz, DMSO-d6) delta 11.19 (s, 1H), 9.80 (s, 2H), 7.59 (d, J = 7.7 Hz, 1H), 7.40 (dd, J = 7.7, 1.2 Hz, 1H), 7.36-7.19 (m, 4H), 7.01 (d, J = 9.0 Hz, 2H), 3.78 (d, J = 12.1 Hz, 2H), 3.50 (d, J = 10.9 Hz, 2H), 3.14 (m, 6H), 2.37 (t, J = 7.3 Hz, 2H), 1.75 (m, 2H), 1.63-1.47 (m, 2H).
The synthetic route of 4570-41-6 has been constantly updated, and we look forward to future research findings.
Reference£º
Article; Cao, Yongkai; Paudel, Suresh; Zhang, Xiaowei; Kim, Kyeong-Man; Cheon, Seung Hoon; Bioorganic and Medicinal Chemistry; vol. 23; 17; (2015); p. 5264 – 5272;,
Benzoxazole – Wikipedia
Benzoxazole | C7H5NO – PubChem