4570-41-6,4570-41-6, Benzo[d]oxazol-2-amine is a benzoxazole compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated
General procedure: To a solution of 4-chloro-6-methylpyrimidin-2-amine (1)(1 mmol) in dry ethanol (4 ml), benzoxazol-2-amine (2a)/benzothiazol-2-amine (2b)/1H-benzimidazol-2-amine (2c)(1.1 mmol) and a catalytic amount of methanesulfonic acid(0.2 ml) were added and refluxed for 5?7 h. After completionof the reaction the contents were cooled and dilutedwith water (15 ml). The separated solid was filtered, washedwith water, dried and recrystallized from 2-propanol. N4-(1,3-Benzoxazol-2-yl)-6-methyl-2,4-pyrimidinediamine(4a)Red solid; yield 74percent; m.p. 138?140 ¡ãC; IR (KBr) vmax 3478(NH2), 3381, 3320 (NH), 1578 (C=N) cm?1; 1H NMR(DMSO?d6, 400 MHz): delta = 2.47 (s, 3H, CH3), 7.01 (s, 1H,C5?H), 7.12 (s, 2H, NH2), 7.33?7.49 (m, 4H, Ar?H), 8.27(bs, 1H, NH); 13C NMR (DMSO?d6, 100 MHz): delta = 24.9(CH3), 96.1 (C?5), 160.4 (C?2?), 164.4 (C?2), 167.5 (C?6),171.9 (C?4), 112.3, 121.6, 125.9, 126.7, 143.4, 152.5(aromatic carbons); MS (m/z): 241.25 [M+]. Anal. Calcd.for C12H11N5O: C, 59.74; H, 4.60; N, 29.03. Found: C,59.86; H, 4.62; N; 29.24.
The synthetic route of 4570-41-6 has been constantly updated, and we look forward to future research findings.
Reference£º
Article; Seenaiah, Dandu; Rekha, Tamatam; Padmaja, Adivireddy; Padmavathi, Venkatapuram; Medicinal Chemistry Research; vol. 26; 2; (2017); p. 431 – 441;,
Benzoxazole – Wikipedia
Benzoxazole | C7H5NO – PubChem