Isolation and identification of new components in the ether-soluble portion of cigarette smoke condensate was written by Newell, Marjorie P.;Heckman, Robert A.;Moates, Robert F.;Green, Charles R.;Best, Freddie W.;Schumacher, J. N.. And the article was included in Tobacco Science in 1978.Synthetic Route of C9H9NO This article mentions the following:
Smoke condensates from 4 different 85-mm nonfiltered, uncased cigarettes smoked under standard conditions were partitioned between ether and water. The ether-soluble material, ∼60% of the total, was chromatographed on silicic acid with increasingly polar solvents to give 7 fractions. Further separation of the fractions by liquid-liquid partitions, column chromatog., and semi-preparative gas-liquid chromatog. led to the isolation and identification of 643 compounds, of which 173 were not previously reported as smoke components. Identification of individual isolates was accomplished by comparison of their IR, NMR, MS, and gas-liquid chromatog. retention times with those of authentic samples. The new isolates include 13 acids, 13 lactones, 2 aldehydes, 56 ketones, 4 alcs., 15 phenols, 19 N heterocyclics, 15 aliphatic hydrocarbons, 33 cyclic hydrocarbons, and 3 miscellaneous compounds A number of these new compounds are known to be in tobacco leaf. In the experiment, the researchers used many compounds, for example, 2,5-Dimethylbenzoxazole (cas: 5676-58-4Synthetic Route of C9H9NO).
2,5-Dimethylbenzoxazole (cas: 5676-58-4) belongs to benzoxazole derivatives. Although benzoxazole itself is of little practical value, many derivatives of benzoxazoles are commercially important. Benzoxazoles are prominent in medicinal chemistry due to their wide spectrum of pharmacological activities such as antibacterial, antifungal, anticancer.Synthetic Route of C9H9NO
Referemce:
Benzoxazole – Wikipedia,
Benzoxazole | C7H5NO – PubChem