Nuclear magnetic resonance study of the benzoxazole derivatives was written by Okuda, Hisashi;Nagai, Makoto. And the article was included in Bulletin of the Chemical Society of Japan in 1967.HPLC of Formula: 5676-58-4 This article mentions the following:
The proton N.M.R. spectra of 2,5-dimethylbenzoxazole, 2,5,7-trimethylbenzoxazole, 2,5,6-trimethylbenzoxazole, 2 methyl-5-chlorobenzoxazole, and 2,4,5-trimethylbenzoxazole are recorded in CCl4 (or CDCl3) and in CF3COOH. In neutral solution, the chem. shifts are interpreted in terms of π-electronic charge ds., magnetic anisotropy of the O and N heteroatoms, and the elec. field effect. Protonation of the N heteroatom in acid solution shifts all of the protons to lower field. To account for the linear dependence of the chem. shifts, corrected for the elec. and anisotropy contributions, with calculated π-electron ds. a proportionality constant of 3.37 ppm./electron is needed. In the experiment, the researchers used many compounds, for example, 2,5-Dimethylbenzoxazole (cas: 5676-58-4HPLC of Formula: 5676-58-4).
2,5-Dimethylbenzoxazole (cas: 5676-58-4) belongs to benzoxazole derivatives. Its aromaticity makes it relatively stable, although as a heterocycle, it has reactive sites which allow for functionalization. In the past years, numerous benzoxazole derivatives have been synthesised and evaluated for their biological potential.HPLC of Formula: 5676-58-4
Referemce:
Benzoxazole – Wikipedia,
Benzoxazole | C7H5NO – PubChem