Heterocyclic Building Blocks-Benzoxazole

Gold(I) complexes of azoles was written by Matovic, Zoran D.;Radanovic, Dusan J.;Ponticelli, G.;Scano, P.;Efimenko, I. A.. And the article was included in Transition Metal Chemistry (Dordrecht, Netherlands) in 1994.COA of Formula: C9H9NO This article mentions the following:

(Di-Me sulfide)AuCl reacts with azoles to give adducts [LAuX]₂ [L = N-methylimidazole (N-MeIm), N-ethylimidazole (N-EtIm), N-propylimidazole (N-PrIm), 2-methylbenzoxazole (2-MeBO) and 2,5-dimethylbanzoxazole (2,5-diMeBO); X = Cl or Br] which were characterized analy. and spectroscopically, including ¹H-n.m.r.I.r. and Raman studies showed that the compounds were binuclear with bridging halogen atoms. A nitrogen-containing ligand was coordinated to nitrogen N(3) atom of the azole ring in monodentate fashion. In the experiment, the researchers used many compounds, for example, 2,5-Dimethylbenzoxazole (cas: 5676-58-4COA of Formula: C9H9NO).

2,5-Dimethylbenzoxazole (cas: 5676-58-4) belongs to benzoxazole derivatives. Although benzoxazole itself is of little practical value, many derivatives of benzoxazoles are commercially important. The wide range in therapeutic potential of benzoxazole derivatives is related to the favourable interactions of the benzoxazole moiety with different protein targets.COA of Formula: C9H9NO

Referemce:
Benzoxazole – Wikipedia,
Benzoxazole | C7H5NO – PubChem

Cyanine dyes with high absorption cross section as donor chromophores in energy transfer primers was written by Hung, Su-Chun;Ju, Jingyue;Mathies, Richard A.;Glazer, Alexander N.. And the article was included in Analytical Biochemistry in 1996.Related Products of 5676-58-4 This article mentions the following:

Energy transfer (ET) fluorescent primers are significantly superior to single dye-labeled primers for DNA sequencing and multiplex genetic analyses (Ju, J. et al., 1996). We describe here ET primers in which a donor chromophore with a large absorption cross section but a low fluorescence quantum yield is exploited to increase the Stokes-shifted fluorescence emission of acceptor dyes. The new ET primers have 3-(ε-carboxypentyl)-3′-ethyl-5,5′-dimethyloxacarbocyanine (CYA; ε_M^488 nm 142,000 M^-1cm^-1) at the 5′-end as a common energy donor, and fluorescein or rhodamine derivatives (FAM, R6G, TAMRA, and ROX), attached to a modified thymidine 10 bases away within the primer sequence, as acceptors. With 488-nm excitation, the fluorescence emission intensity of these 4 ET primers is 1.4-24-fold stronger than that of the corresponding primers labeled only with the single acceptor dye. When compared with the corresponding ET primers with a fluorescein derivative (FAM; ε_M^488 nm 60,000 M^-1 cm^-1) as donor, the fluorescence emissions of primers with CYA as donor and FAM, R6G, TAMRA, and ROX as acceptors are 0.8-, 1.0-, 1.7-, and 1.7-fold, resp., as intense. The low fluorescence quantum yield of the CYA donor resulted in distinct fluorescence signals for the DNA-sequencing fragments with much lower crosstalk between the 4 detection channels than that seen with ET primers based on a FAM donor. With single-stranded M13mp18 DNA as the template, the CYA ET primers provided DNA sequences on a 4-color capillary sequencer with 100% accuracy in the first 500 bases. In the experiment, the researchers used many compounds, for example, 2,5-Dimethylbenzoxazole (cas: 5676-58-4Related Products of 5676-58-4).

2,5-Dimethylbenzoxazole (cas: 5676-58-4) belongs to benzoxazole derivatives. Benzoxazole derivatives have gained a lot of importance in the past few years because of their use in intermediates for the preparation of new biological materials. Benzoxazoles are prominent in medicinal chemistry due to their wide spectrum of pharmacological activities such as antibacterial, antifungal, anticancer.Related Products of 5676-58-4

Referemce:
Benzoxazole – Wikipedia,
Benzoxazole | C7H5NO – PubChem

Gold(III) complexes with imidazole, benzoxazole, purine and pyrimidine derivatives was written by Radanovic, Dusan J.;Matovic, Zoran D.;Ponticelli, Gustavo;Scano, Paola;Efimenko, Inessa A.. And the article was included in Transition Metal Chemistry (Dordrecht, Netherlands) in 1994.SDS of cas: 5676-58-4 This article mentions the following:

The synthesis and characterization of Au^III complexes with several heterocyclic ligands are reported. The compounds are [AuX₃(L)], where L = N-methylimidazole (N-MeIz), N-ethylimidazole (N-EtIz), N-propylimidazole (N-PrIz), benzoxazole (BO), 2-methylbenzoxazole (2-MeBO), 2,5-dimethylbenzoxazole (2,5-diMeBO), 2-aminopyrimidine (2-APm), 4(6)-hydroxypyrimidine [4(6)-hydrPm] or hypoxanthine (Hypox) and X = Cl or Br. Elemental anal., conductivity measurements and spectral studies were used for the characterization of the complexes. A square-planar geometry with N-bonded heterocyclic ligands is suggested. In the experiment, the researchers used many compounds, for example, 2,5-Dimethylbenzoxazole (cas: 5676-58-4SDS of cas: 5676-58-4).

2,5-Dimethylbenzoxazole (cas: 5676-58-4) belongs to benzoxazole derivatives. Benzoxazole derivatives have gained a lot of importance in the past few years because of their use in intermediates for the preparation of new biological materials. The wide range in therapeutic potential of benzoxazole derivatives is related to the favourable interactions of the benzoxazole moiety with different protein targets.SDS of cas: 5676-58-4

Referemce:
Benzoxazole – Wikipedia,
Benzoxazole | C7H5NO – PubChem

Homo- and Heteroannulation of sp³ C-H Bonds in Acetophenones for Divergent Synthesis of Thienothiazoles was written by Pham, Phuc H.;Nguyen, Khang X.;Pham, Hoai T. B.;Nguyen, Tung T.;Phan, Nam T. S.. And the article was included in Organic Letters in 2019.Safety of 2,5-Dimethylbenzoxazole This article mentions the following:

A synthesis of fused thieno[3,2-d]thiazoles I (R = H, Me, OMe, etc.) via direct functionalization of C(sp³)-H bonds in acetophenones was reported. The transformation is divergent to afford either 2-phenylbenzo[4,5]thieno[3,2-d]thiazoles or benzo[4,5]thieno[3,2-d]thiazol-2-yl(phenyl)methanones. Cross-coupling of acetophenones with C-H bonds in phenylacetic acids, methylazaarenes, and aldehydes was also feasible. Excellent tolerance of functionalities was observed This method marks a rare functionalization of C(sp³)-H bonds in acetophenones to obtain heterocycles in the absence of pre-functionalized oxime esters. In the experiment, the researchers used many compounds, for example, 2,5-Dimethylbenzoxazole (cas: 5676-58-4Safety of 2,5-Dimethylbenzoxazole).

2,5-Dimethylbenzoxazole (cas: 5676-58-4) belongs to benzoxazole derivatives. Being a heterocyclic compound, benzoxazole finds use in research as a starting material for the synthesis of larger, usually bioactive structures. A number of marketed drugs are available having benzoxazole as core active moiety like, nonsteroidal anti-inflammatory drug (NSAID)—flunoxaprofen, benoxaprofen, antibiotic—calcimycin.Safety of 2,5-Dimethylbenzoxazole

Referemce:
Benzoxazole – Wikipedia,
Benzoxazole | C7H5NO – PubChem

Structure and reactivity of benzoxazoles: carbon-13 nuclear magnetic resonance study was written by Llinares, Jeanine;Galy, Jean Pierre;Faure, Robert;Vincent, Emile Jean;Elguero, Jose. And the article was included in Canadian Journal of Chemistry in 1979.Formula: C9H9NO This article mentions the following:

Thirty-four benzoxazoles, oxazole, and 10 o-aminophenols were studied by ¹³C NMR spectroscopy. All the signals are attributed to substituent effects. The structures of the products obtained by the nitration of benzoxazole were determined by ¹³C NMR. The shifts induced by substitution at the 2 position are discussed as a function of an empirical model by using the structural parameters F, R, and Q^*. Azido-tetrazole equilibrium (N₃ in position 2) and prototropic tautomerism (NH₂, OH, and SH in position 2) are also discussed. The chem. shifts and coupling constants of oxazole and unsubstituted benzoxazole are compared. In the experiment, the researchers used many compounds, for example, 2,5-Dimethylbenzoxazole (cas: 5676-58-4Formula: C9H9NO).

2,5-Dimethylbenzoxazole (cas: 5676-58-4) belongs to benzoxazole derivatives. Benzoxazoles belong to the group of well-known antifungal agents with antioxidant, antiallergic, antitumoral and antiparasitic activity. Benzoxazoles are prominent in medicinal chemistry due to their wide spectrum of pharmacological activities such as antiparkinson, inhibition of hepatitis C virus, 5-HT3 antagonistic effect.Formula: C9H9NO

Referemce:
Benzoxazole – Wikipedia,
Benzoxazole | C7H5NO – PubChem

Nano ceria catalyzed synthesis of substituted benzimidazole, benzothiazole, and benzoxazole in aqueous media was written by Shelkar, Radheshyam;Sarode, Sachin;Nagarkar, Jayashree. And the article was included in Tetrahedron Letters in 2013.Electric Literature of C13H8BrNO This article mentions the following:

A series of substituted benzimidazoles, benzothiazoles, and benzoxazoles was synthesized by combining 1,2-phenylenediamine, 2-aminothiophenol, or 2-aminophenol with aryl, heteroaryl, aliphatic, α,β-unsaturated aldehydes in the presence of nano ceria (CeO₂) as an efficient heterogeneous catalyst. In the experiment, the researchers used many compounds, for example, 2-(3-Bromophenyl)benzo[d]oxazole (cas: 99586-31-9Electric Literature of C13H8BrNO).

2-(3-Bromophenyl)benzo[d]oxazole (cas: 99586-31-9) belongs to benzoxazole derivatives. Benzoxazoles belong to the group of well-known antifungal agents with antioxidant, antiallergic, antitumoral and antiparasitic activity. It is found within the chemical structures of pharmaceutical drugs such as flunoxaprofen and tafamidis.Electric Literature of C13H8BrNO

Referemce:
Benzoxazole – Wikipedia,
Benzoxazole | C7H5NO – PubChem

A TEMPO-Functionalized Ordered Mesoporous Polymer as a Highly Active and Reusable Organocatalyst was written by Guo, Ying;Wang, Wei David;Li, Shengyu;Zhu, Yin;Wang, Xiaoyu;Liu, Xiao;Zhang, Yuan. And the article was included in Chemistry – An Asian Journal in 2021.Reference of 99586-31-9 This article mentions the following:

The properties of high stability, periodic porosity, and tunable nature of ordered mesoporous polymers make these materials ideal catalytic nanoreactors. However, their application in organocatalysis has been rarely explored. We report herein for the first time the incorporation of a versatile organocatalyst, 2,2,6,6-tetramethyl-1-piperidinyloxy (TEMPO), into the pores of an FDU-type mesoporous polymer via a pore surface engineering strategy. The resulting FDU-15-TEMPO possesses a highly ordered mesoporous organic framework and enhanced stability, and shows excellent catalytic activity in the selective oxidation of alcs. and aerobic oxidative synthesis of 2-substituted benzoxazoles, benzimidazoles and benzothiazoles. Moreover, the catalyst can be easily recovered and reused for up to 7 consecutive cycles. In the experiment, the researchers used many compounds, for example, 2-(3-Bromophenyl)benzo[d]oxazole (cas: 99586-31-9Reference of 99586-31-9).

2-(3-Bromophenyl)benzo[d]oxazole (cas: 99586-31-9) belongs to benzoxazole derivatives. Although benzoxazole itself is of little practical value, many derivatives of benzoxazoles are commercially important. Due to its versatile biological properties, benzoxazole has been incorporated as an essential pharmacophore and substructure in many medicinal compounds.Reference of 99586-31-9

Referemce:
Benzoxazole – Wikipedia,
Benzoxazole | C7H5NO – PubChem

Indium-mediated one-pot synthesis of benzoxazoles or oxazoles from 2-nitrophenols or 1-aryl-2-nitroethanones was written by Lee, Jung June;Kim, Jihye;Jun, Young Moo;Lee, Byung Min;Kim, Byeong Hyo. And the article was included in Tetrahedron in 2009.HPLC of Formula: 5676-58-4 This article mentions the following:

One-pot reduction-triggered heterocyclizations from 2-nitrophenols to benzoxazoles and from 1-aryl-2-nitroethanones to oxazoles were investigated. In the presence of indium/AcOH in benzene at reflux, 2-nitrophenols and R-C(OMe)₃ (R=H, Me, Ph) produced excellent yields of corresponding benzoxazoles within an hour. Similarly, 1-aryl-2-nitroethanones and Ph-C(OMe)₃ in the presence of indium/AcOH in acetonitrile transformed into the corresponding oxazoles with good yields. In the experiment, the researchers used many compounds, for example, 2,5-Dimethylbenzoxazole (cas: 5676-58-4HPLC of Formula: 5676-58-4).

2,5-Dimethylbenzoxazole (cas: 5676-58-4) belongs to benzoxazole derivatives. Its aromaticity makes it relatively stable, although as a heterocycle, it has reactive sites which allow for functionalization. A number of marketed drugs are available having benzoxazole as core active moiety like, nonsteroidal anti-inflammatory drug (NSAID)—flunoxaprofen, benoxaprofen, antibiotic—calcimycin.HPLC of Formula: 5676-58-4

Referemce:
Benzoxazole – Wikipedia,
Benzoxazole | C7H5NO – PubChem

Metal-free direct annulation of 2-aminophenols and 2-aminothiophenols with unactivated amides through transamidation: Access to polysubstituted benzoxazole and benzothiazole derivatives was written by Kumar, Vishal;Dhawan, Sanjeev;Bala, Renu;Girase, Pankaj Sanjay;Singh, Parvesh;Karpoormath, Rajshekhar. And the article was included in Tetrahedron in 2022.Name: 2,5-Dimethylbenzoxazole This article mentions the following:

Simple yet novel oxidant, metal and solvent-free green protocol for synthesizing differently 2-substituted 1,3-benzoxazoles I [R¹ = Me, Ph, Bn, etc.; R² = H, 6-Me, 5-Cl, etc.; X = O] and benzothiazoles I [R¹ = Me; R² = H, 5-Cl; X = S] from 2-aminophenol hydrochloride salt, unactivated amide as in situ carbon source was reported. Further, the hydrogen ion of hydrochloride played a crucial role in amide activation followed nucleophilic attack that through eliminations of amine as a side product, and de-hydrolysis step leads to final annulation. This versatile strategy was applicable to a wide variety of differently substituted o-aminophenols, unactivated aliphatic and aromatic amides, yielding the corresponding product in good to excellent yields in a single step. In the experiment, the researchers used many compounds, for example, 2,5-Dimethylbenzoxazole (cas: 5676-58-4Name: 2,5-Dimethylbenzoxazole).

2,5-Dimethylbenzoxazole (cas: 5676-58-4) belongs to benzoxazole derivatives. Benzoxazole derivatives have gained a lot of importance in the past few years because of their use in intermediates for the preparation of new biological materials. Due to its versatile biological properties, benzoxazole has been incorporated as an essential pharmacophore and substructure in many medicinal compounds.Name: 2,5-Dimethylbenzoxazole

Referemce:
Benzoxazole – Wikipedia,
Benzoxazole | C7H5NO – PubChem

Some novel reactions of benzoxazole derivatives with dimethyl acetylenedicarboxylate. II was written by Kawahara, Norio;Katsuyama, Michiko;Itoh, Tsuneo;Ogura, Haruo. And the article was included in Heterocycles in 1981.Reference of 5676-58-4 This article mentions the following:

Reaction of 2-alkylbenzoxazoles I (R, R¹ = H, H; Me, H; Me, Me) with R²CCR² (R² = CO₂Me) in EtOH or CMe₃OH at room temperature gave tricyclic compound II, hydration product III (R³ = H), solvent adduct III (R³ = CMe₃), and ring-opened compounds RC₆H₃(O₂CCH₂R¹)NHCR²:CHR²-4,3 and RC₆H₃(OH)[N(COCH₂R¹)CR²:CHR²]-4,3 (IV). IV was a main product of photochem. reaction of I with R²CCR². In the experiment, the researchers used many compounds, for example, 2,5-Dimethylbenzoxazole (cas: 5676-58-4Reference of 5676-58-4).

2,5-Dimethylbenzoxazole (cas: 5676-58-4) belongs to benzoxazole derivatives. Its aromaticity makes it relatively stable, although as a heterocycle, it has reactive sites which allow for functionalization. Due to its versatile biological properties, benzoxazole has been incorporated as an essential pharmacophore and substructure in many medicinal compounds.Reference of 5676-58-4

Referemce:
Benzoxazole – Wikipedia,
Benzoxazole | C7H5NO – PubChem