Heterocyclic Building Blocks-Benzoxazole

Biodegradation of three selected benzotriazoles under aerobic and anaerobic conditions was written by Liu, You-Sheng;Ying, Guang-Guo;Shareef, Ali;Kookana, Rai S.. And the article was included in Water Research in 2011.HPLC of Formula: 5676-58-4 This article mentions the following:

We examined the biodegradability of three benzotriazoles (benzotriazole: BT, 5-methylbenzotriazole: 5-TTri and 5-chlorobenzotriazole: CBT) under aerobic and anaerobic (nitrate, sulfate, and Fe (III) reducing) conditions. All three benzotriazoles were degraded by microorganisms under aerobic and anaerobic conditions. Both the biodegradation efficiency and biodegradation products were dependent on the predominant terminal electron-accepting condition. Among the redox conditions studied, the shortest biodegradation half lives for BT and 5-TTri were 114 days and 14 days, resp., under aerobic condition. The shortest half-life for CBT was 26 days under Fe (III) reducing condition. The longest biodegradation half lives for BT and CBT were 315 days and 96 days, resp., under sulfate reducing condition, while that of 5-TTri was 128 days under nitrate reducing condition. These results suggest that aerobic biodegradation is the dominant natural attenuation mechanism for BT and 5-TTri, while the most favorable process for CBT was anaerobic biodegradation This study demonstrated that different predominant terminal electron-acceptors present in natural environment play a key role on the biodegradation of BT, 5-TTri and CBT, leading to specific biodegradability. This could have significant implications on in-situ biodegradation of the selected benzotriazoles in aerobic and anaerobic waters, soils and sediments. In the experiment, the researchers used many compounds, for example, 2,5-Dimethylbenzoxazole (cas: 5676-58-4HPLC of Formula: 5676-58-4).

2,5-Dimethylbenzoxazole (cas: 5676-58-4) belongs to benzoxazole derivatives. Benzoxazole derivatives have gained a lot of importance in the past few years because of their use in intermediates for the preparation of new biological materials. In the past years, numerous benzoxazole derivatives have been synthesised and evaluated for their biological potential.HPLC of Formula: 5676-58-4

Referemce:
Benzoxazole – Wikipedia,
Benzoxazole | C7H5NO – PubChem

A rapid and efficient microwave-assisted synthesis of 2-arylbenzoxazoles by using 1,3-dibromo-5,5-dimethylhydantoin (DBH) under solvent-free condition was written by Shinde, Kailas W.;Keche, Ashish P.. And the article was included in Journal of Chemical and Pharmaceutical Research in 2016.Application In Synthesis of 2-(3-Bromophenyl)benzo[d]oxazole This article mentions the following:

A simple, rapid and efficient procedure for the synthesis of 2-arylbenzoxazole derivatives I [R= H, Me, MeO, Cl; R¹ = 3-Me, 3-MeO, 3-NO₂-4-Cl, etc.] was developed from 2-aminophenol and arylaldehydes by using 1,3-dibromo-5,5-dimethylhydantoin (DBH) in moderate to good yields under solvent-free microwave irradiation The remarkable efficiency of DBH under solvent free microwave irradiation led many advantages like, the use of non-corrosive, inexpensive reagents, simple workup procedure, in addition to the eco-friendly green chem. economical and environmental impacts. In the experiment, the researchers used many compounds, for example, 2-(3-Bromophenyl)benzo[d]oxazole (cas: 99586-31-9Application In Synthesis of 2-(3-Bromophenyl)benzo[d]oxazole).

2-(3-Bromophenyl)benzo[d]oxazole (cas: 99586-31-9) belongs to benzoxazole derivatives. Benzoxazole nucleus is one of the most important heterocyclic compounds exhibiting remarkable pharmacological activities. A number of marketed drugs are available having benzoxazole as core active moiety like, nonsteroidal anti-inflammatory drug (NSAID)—flunoxaprofen, benoxaprofen, antibiotic—calcimycin.Application In Synthesis of 2-(3-Bromophenyl)benzo[d]oxazole

Referemce:
Benzoxazole – Wikipedia,
Benzoxazole | C7H5NO – PubChem

Infrared spectra of some compounds with thiazole and oxazole rings. The C:N bond was written by Bassignana, P.;Cogrossi, C.;Gandino, M.. And the article was included in Spectrochimica Acta in 1963.Quality Control of 2,5-Dimethylbenzoxazole This article mentions the following:

Examination of the IR spectra in the solid state of some compounds with the thiazole and oxazole rings shows regularities in the 1690-1480 cm.^-1 region. Absorption bands at 1680-1600 and 1585-1500 cm.^-1 were assigned to the vibrations arising from the heterocyclic ring system. The synthetic methods are described for these thiazole and oxazole derivatives which have not been reported previously. In the experiment, the researchers used many compounds, for example, 2,5-Dimethylbenzoxazole (cas: 5676-58-4Quality Control of 2,5-Dimethylbenzoxazole).

2,5-Dimethylbenzoxazole (cas: 5676-58-4) belongs to benzoxazole derivatives. Benzoxazole derivatives have gained a lot of importance in the past few years because of their use in intermediates for the preparation of new biological materials. The wide range in therapeutic potential of benzoxazole derivatives is related to the favourable interactions of the benzoxazole moiety with different protein targets.Quality Control of 2,5-Dimethylbenzoxazole

Referemce:
Benzoxazole – Wikipedia,
Benzoxazole | C7H5NO – PubChem

Chlorination and ortho-acetoxylation of 2-arylbenzoxazoles was written by Leng, Yuting;Yang, Fan;Zhu, Weiguo;Wu, Yangjie;Li, Xiang. And the article was included in Organic & Biomolecular Chemistry in 2011.Product Details of 99586-31-9 This article mentions the following:

Efficient and facile catalytic protocols for chlorination and ligand-directed ortho-acetoxylation of 2-arylbenzoxazoles have been developed. The chlorination is not a ligand-directed ortho-functionalization, but an electrophilic substitution process in the benzo ring of the benzoxazole moiety. Meanwhile, the acetoxylation exhibited high regioselectivity for the substrates containing a meta-substituent and occurred at the less sterically hindered ortho-C-H bond of the directing group. In the experiment, the researchers used many compounds, for example, 2-(3-Bromophenyl)benzo[d]oxazole (cas: 99586-31-9Product Details of 99586-31-9).

2-(3-Bromophenyl)benzo[d]oxazole (cas: 99586-31-9) belongs to benzoxazole derivatives. The benzoxazole moiety is widely found in various natural compounds, which are often found to be biologically active. In the past years, numerous benzoxazole derivatives have been synthesised and evaluated for their biological potential.Product Details of 99586-31-9

Referemce:
Benzoxazole – Wikipedia,
Benzoxazole | C7H5NO – PubChem

Synthesis through microwave irradiation, characterization and evaluation of antimicrobial activity of 2-phenyl-1,3-benzoxazole derivatives was written by Tariq, Sana;Wakode, Sharad. And the article was included in International Research Journal of Pharmacy in 2012.HPLC of Formula: 99586-31-9 This article mentions the following:

2-Phenyl-1,3-benzoxazoles were synthesized by the reaction of 2-aminophenol and acyl chlorides using microwave irradiation The compounds were evaluated for in-vitro antimicrobial activity against Bacillus pumilus, Bacillus subtilis (Gram pos.); Escherichia coli, Pseudomonas aeruginosa (Gram neg.); and Candida albicans and Aspergillus niger by agar-well diffusion at 2.5, 5, and 10 mg/mL. 2-(2-Methoxyphenyl)-, 2-(4-bromophenyl)-, 2-(3-chlorophenyl)-, and 2-(2-nitrophenyl)-1,3-benzoxazole exhibited good antibacterial activity. 2-Phenyl- and 2-(4-bromophenyl)-1,3-benzoxazole were potent antifungal compounds amongst the series. In the experiment, the researchers used many compounds, for example, 2-(3-Bromophenyl)benzo[d]oxazole (cas: 99586-31-9HPLC of Formula: 99586-31-9).

2-(3-Bromophenyl)benzo[d]oxazole (cas: 99586-31-9) belongs to benzoxazole derivatives. Benzoxazole nucleus is one of the most important heterocyclic compounds exhibiting remarkable pharmacological activities. Benzoxazoles are prominent in medicinal chemistry due to their wide spectrum of pharmacological activities such as anti-inflammatory, antimycobacterial, antihistamine.HPLC of Formula: 99586-31-9

Referemce:
Benzoxazole – Wikipedia,
Benzoxazole | C7H5NO – PubChem

Facile Preparation of Benzoxazoles from S₈-Promoted Cyclization of 2-Nitrophenols with Arylmethyl Chloride was written by Gan, Haifeng. And the article was included in ChemistrySelect in 2019.Application In Synthesis of 2-(3-Bromophenyl)benzo[d]oxazole This article mentions the following:

A simple, metal-free methodol. has been obtained for the preparation of 2-arylbenzoxazoles I (R = H, 6-Me, 5-NHC(O)CH₃, etc.; R¹ = Ph, naphthalen-2-yl, pyridin-4-yl, etc.) from 2-nitrophenols 2-NO₂-R² -C₆H₃OH (R = H, 5-Me, 4-F, etc.) and arylmethyl chlorides R¹CH₂Cl via an elemental sulfur-promoted cyclization reaction. The reactions proceeded in moderate to good yields, and gram-scale is applicable. In the experiment, the researchers used many compounds, for example, 2-(3-Bromophenyl)benzo[d]oxazole (cas: 99586-31-9Application In Synthesis of 2-(3-Bromophenyl)benzo[d]oxazole).

2-(3-Bromophenyl)benzo[d]oxazole (cas: 99586-31-9) belongs to benzoxazole derivatives. The benzoxazole moiety is widely found in various natural compounds, which are often found to be biologically active. Due to its versatile biological properties, benzoxazole has been incorporated as an essential pharmacophore and substructure in many medicinal compounds.Application In Synthesis of 2-(3-Bromophenyl)benzo[d]oxazole

Referemce:
Benzoxazole – Wikipedia,
Benzoxazole | C7H5NO – PubChem

Synthesis of Benz-Fused Azoles via C-Heteroatom Coupling Reactions Catalyzed by Cu(I) in the Presence of Glycosyltriazole Ligands was written by Mishra, Nidhi;Singh, Anoop S.;Agrahari, Anand K.;Singh, Sumit K.;Singh, Mala;Tiwari, Vinod K.. And the article was included in ACS Combinatorial Science in 2019.Electric Literature of C13H8BrNO This article mentions the following:

D-Glucose-derived triazoles such as I were prepared for use as ligands in coupling and tandem coupling and cyclization reactions using CuI as catalyst and K₂CO₃ in DMF to yield benzoxazoles, benzothiazoles, benzimidazoles, arylaminobenzothiazoles, and benzimidazoquinazolinones. In the experiment, the researchers used many compounds, for example, 2-(3-Bromophenyl)benzo[d]oxazole (cas: 99586-31-9Electric Literature of C13H8BrNO).

2-(3-Bromophenyl)benzo[d]oxazole (cas: 99586-31-9) belongs to benzoxazole derivatives. The benzoxazole moiety is widely found in various natural compounds, which are often found to be biologically active. The wide range in therapeutic potential of benzoxazole derivatives is related to the favourable interactions of the benzoxazole moiety with different protein targets.Electric Literature of C13H8BrNO

Referemce:
Benzoxazole – Wikipedia,
Benzoxazole | C7H5NO – PubChem

Inhibitors of hepatic mixed function oxidases. II. Some benzimidazole, benzoxazole and benzothiazole derivatives was written by Holder, Gerald M.;Little, Peter J.;Ryan, Adrian J.;Watson, Thomas R.. And the article was included in Biochemical Pharmacology in 1976.Application of 5676-58-4 This article mentions the following:

Aminopyrine N-demethylase [9037-69-8] activity in rat liver microsomes was inhibited by 19 benzimidazole derivatives (e.g. I [615-15-6]), 2 benzoxazole derivatives, and 2 benzothiazole derivatives with 50% inhibitory concentrations (I50) ranging from 1.5 × 10-5M to 108 × 10-5M. Aniline p-hydroxylase [9012-80-0] activity was inhibited by all but 4 of these compounds, with I50 from 16 × 10-5M to 360 × 10-5M, and was stimulated by 3 of the compounds The I50 decreased with increasing lipophilicity caused by extension of the alkyl side chain and modification of the heterocyclic ring. The I50s for inhibition of each enzyme were correlated with the octanol/water partition coefficient of the compounds Quinalbarbitone [309-43-3] sleeping time in mice was increased by 14 out of 16 of the compounds tested. In the experiment, the researchers used many compounds, for example, 2,5-Dimethylbenzoxazole (cas: 5676-58-4Application of 5676-58-4).

2,5-Dimethylbenzoxazole (cas: 5676-58-4) belongs to benzoxazole derivatives. Its aromaticity makes it relatively stable, although as a heterocycle, it has reactive sites which allow for functionalization. Due to its versatile biological properties, benzoxazole has been incorporated as an essential pharmacophore and substructure in many medicinal compounds.Application of 5676-58-4

Referemce:
Benzoxazole – Wikipedia,
Benzoxazole | C7H5NO – PubChem

Microwave-assisted efficient one-step synthesis of amides from ketones and benzoxazoles from (2-hydroxyaryl) ketones with acetohydroxamic acid using sulfuric acid as the catalyst was written by Madabhushi, Sridhar;Chinthala, Narsaiah;Vangipuram, Venkata Sairam;Godala, Kondal Reddy;Jillella, Raveendra;Mallu, Kishore Kumar Reddy;Beeram, China Ramanaiah. And the article was included in Tetrahedron Letters in 2011.SDS of cas: 5676-58-4 This article mentions the following:

An efficient 1-step method for the synthesis of amides and benzoxazoles directly from ketones and 2-hydroxyaryl ketones, resp., by the reaction with AcNHOH using H₂SO₄ as catalyst was described. In the experiment, the researchers used many compounds, for example, 2,5-Dimethylbenzoxazole (cas: 5676-58-4SDS of cas: 5676-58-4).

2,5-Dimethylbenzoxazole (cas: 5676-58-4) belongs to benzoxazole derivatives. The benzoxazole moiety is widely found in various natural compounds, which are often found to be biologically active. The wide range in therapeutic potential of benzoxazole derivatives is related to the favourable interactions of the benzoxazole moiety with different protein targets.SDS of cas: 5676-58-4

Referemce:
Benzoxazole – Wikipedia,
Benzoxazole | C7H5NO – PubChem

Long-Chained Acidic Ionic Liquids-Catalyzed Cyclization of 2-Substituted Aminoaromatics with β-Diketones: A Metal-Free Strategy to Construct Benzoazoles was written by Miao, Chengxia;Hou, Qin;Wen, Yating;Han, Feng;Li, Zhen;Yang, Lei;Xia, Chun-Gu. And the article was included in ACS Sustainable Chemistry & Engineering in 2019.HPLC of Formula: 5676-58-4 This article mentions the following:

With long-chained acidic ionic liquids as catalysts, a metal-free, efficient, and universal strategy was developed to synthesize a series of benzoazole compounds through intermol. cyclization of 2-aminophenols/thiophenols/anilines with β-diketones. Compared with traditional ionic liquids, the long-chained ionic liquids with certain surfactivity exhibited better catalytic activities perhaps for micellar action and could be reused at least six times. A mechanism that involves condensation, nucleophilic addition, and C-C bond cleavage was proposed, and the imine compound was recognized as an important intermediate in the reaction. In the experiment, the researchers used many compounds, for example, 2,5-Dimethylbenzoxazole (cas: 5676-58-4HPLC of Formula: 5676-58-4).

2,5-Dimethylbenzoxazole (cas: 5676-58-4) belongs to benzoxazole derivatives. Its aromaticity makes it relatively stable, although as a heterocycle, it has reactive sites which allow for functionalization. A number of marketed drugs are available having benzoxazole as core active moiety like, nonsteroidal anti-inflammatory drug (NSAID)—flunoxaprofen, benoxaprofen, antibiotic—calcimycin.HPLC of Formula: 5676-58-4

Referemce:
Benzoxazole – Wikipedia,
Benzoxazole | C7H5NO – PubChem