Heterocyclic Building Blocks-Benzoxazole

Chemistry can be defined as the study of matter and the changes it undergoes. You’ll sometimes hear it called the central science because it is the connection between physics and all the other sciences, starting with biology. 301353-96-8, Name is P7C3, molecular formula is , belongs to benzoxazole compound. In a document, author is Karaaslan, Cigdcm, Product Details of 301353-96-8.

Synthesis & Anticancer Evaluation of New Substituted 2-(3,4-Dimethoxyphenyl)benzazoles

Background: The benzazole nucleus is found in many promising small molecules such as anticancer and antibacterial agents. Bendamustine (Alkylating agent), Nocodazole (Mitotic inhibitor), Veliparib (PARP inhibitor), and Glasdegib (SMO inhibitor) are being clinically used as anticancer therapeutic which bear benzimidazole moiety. Based on the principle of bioisosterism, in the present work, 23 compounds belonging to 2-(3,4-dimethoxyphenyl)benzazoles and imidazopyridine series were synthesized and evaluated for their anticancer and antimicrobial activities. Objective: A series of new 2-(3,4-dimetboxyphenyl)-1H-benz(or pyrido)azoles were synthesized and evaluated for their anticancer and antimicrobial activities. Method: N-(5-chloro-2-hdroxyphenyl)-3,4-dimethoxybenzamide 1, was obtained by the amidation of 2-hydroxy-5-chloroaniline with 3,4-dimethoxybenzoic acid by using 1,1′-carbonyldiimidazole. Cyclization of 1 to benzoxazole derivative 2, was achieved by p-toluenesulfonic acid. Other 1H-benz(or pyrido)azoles were prepared by the reaction between 2-aminothiophenol, o-phenylenediamine, o-pyridinediamine with sodium metabisulfite adduct of 3,4-dimethoxybenzaldehyde. The NMR assignments of the dimethoxy groups were established by the NOESY spectra. Results: Compound 12, bearing two chlorine atoms at the 5(4) and 7(6) positions of the benzene moiety of benzimidazole was found the most potent analogue against A549 cells with the GI(50) value of 1.5 mu g/mL. Moreover, 24 showed remarkable cell growth inhibition against MCF-7 and HeLa cells with the GI(50) values of 7 and 5.5 mu g/mL, respectively. The synthesized compounds have no important antibacterial and antifimgal activities. Conclusion: It could be concluded that the introduction of di-chloro atoms at the phenyl ring of 2-(3,4-dimetboxyphenyl)-1H-benzimidawles increases significant cytotoxicity to selected human tumor cell lines in comparison to other all benzazoles synthesized. Unsubstituted 2-(3,4-dimethoxyphenyl)-imidazopyridines also gave good inhibitory profile against A549 and HeLa cells.

Sometimes chemists are able to propose two or more mechanisms that are consistent with the available data. If a proposed mechanism predicts the wrong experimental rate law, however, the mechanism must be incorrect.Welcome to check out more blogs about 301353-96-8, in my other articles. Product Details of 301353-96-8.

Reference:
Benzoxazole – Wikipedia,
,Benzoxazole | C7H5NO – PubChem

Synthetic Route of 421-85-2, Redox catalysis has been broadly utilized in electrochemical synthesis due to its kinetic advantages over direct electrolysis. The appropriate choice of redox mediator can avoid electrode passivation and overpotential. 421-85-2, Name is Trifluoromethanesulfonamide, SMILES is O=S(C(F)(F)F)(N)=O, belongs to benzoxazole compound. In a article, author is Liu, Dan, introduce new discover of the category.

A water-soluble benzoxazole-based probe: Real-time monitoring PPi via situ reaction by two-photon cells imaging

Pyrophosphate (PPi) played crucial roles in various fundamental physiological processes. Herein, a two-photon absorption (TPA) On-Off-On type benzoxazole-based fluorescence probe BN was designed and synthesized, which detected PPi through Cu2+ displacing method in situ system in aqueous medium. The on-off-on process of BN recognizing PPi was verified by mass spectra and theoretical calculations, which was successfully applied in TPA cells imaging.

Synthetic Route of 421-85-2, Each elementary reaction can be described in terms of its molecularity, the number of molecules that collide in that step. The slowest step in a reaction mechanism is the rate-determining step.you can also check out more blogs about 421-85-2.

Reference:
Benzoxazole – Wikipedia,
,Benzoxazole | C7H5NO – PubChem

The reaction rate of a catalyzed reaction is faster than the reaction rate of the uncatalyzed reaction at the same temperature. 372-38-3, Name is 1,3,5-Trifluorobenzene, SMILES is FC1=CC(F)=CC(F)=C1, in an article , author is Shafaei, Faezeh, once mentioned of 372-38-3, Product Details of 372-38-3.

Biosynthesis of Fe3O4-magnetic nanoparticles using clover leaf aqueous extract: Green synthesis of 1,3-benzoxazole derivatives

In this research, magnetic Fe3O4-NP nanoparticles were synthesized employing a green biosynthetic procedure by reduction of ferric chloride solution with clover leaf water extract. The nanoparticles prepared via this biosynthesis method can potentially be valuable for different purposes such as organic synthesis. In this research, 1,3-benzoxazole derivatives were generated via a multicomponent reaction of alpha-bromo ketones, isothiocyanate, and propiolate in the presence of a catalytic amount of bio-Fe3O4 MNPs and sodium hydride in water at 50 degrees C in good yields. The catalyst was reused five times with a minor decrease in its catalytic activity.

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Reference:
Benzoxazole – Wikipedia,
,Benzoxazole | C7H5NO – PubChem

A catalyst don’t appear in the overall stoichiometry of the reaction it catalyzes, but it must appear in at least one of the elementary reactions in the mechanism for the catalyzed reaction. 105832-38-0, Name is 2-(2,5-Dioxopyrrolidin-1-yl)-1,1,3,3-tetramethylisouronium tetrafluoroborate, molecular formula is C9H16BF4N3O3. In an article, author is Watanabe, Genki,once mentioned of 105832-38-0, Name: 2-(2,5-Dioxopyrrolidin-1-yl)-1,1,3,3-tetramethylisouronium tetrafluoroborate.

Synthesis and Antimicrobial Activity of 2-Trifluoroacetonylbenzoxazole Ligands and Their Metal Complexes

Three 2-fluoroacetonylbenzoxazole ligands 1a-c and their new Zn(II) complexes 2a-c have been synthesized. In addition, syntheses of new metal [Mg(II), Ni(II), Cu(II), Pd(II), and Ag(I)] complexes from la have been also described. The molecular and crystal structures of six metal complexes 2b and 2d-h were determined by single-crystal X-ray diffraction analyses. Their antibacterial activities against six Gram-positive and six Gram-negative bacteria were evaluated by minimum inhibitory concentrations (MIC), which were compared with those of appropriate antibiotics and silver nitrate. The results indicate that some metal compounds have more antibacterial effects in comparison with free ligands and have preferred antibacterial activities that may have potential pharmaceutical applications. Noticeably, the Ag(I) complex 2h exhibited low MIC value of 0.7 mu m against Pseudomonas aeruginosa, which was even superior to the reference drug, Norfloxacin with that of 1.5 mu m. Against P. aeruginosa, 2h is bacteriostatic, exerts the cell surface damage observed by scanning electron microscopy (SEM) and is less likely to develop resistance. The new 2h has been found to display effective antimicrobial activity against a series of bacteria.

Interested yet? Keep reading other articles of 105832-38-0, you can contact me at any time and look forward to more communication. Name: 2-(2,5-Dioxopyrrolidin-1-yl)-1,1,3,3-tetramethylisouronium tetrafluoroborate.

Reference:
Benzoxazole – Wikipedia,
,Benzoxazole | C7H5NO – PubChem

Enzymes are biological catalysts that produce large increases in reaction rates and tend to be specific for certain reactants and products. 372-38-3, Name is 1,3,5-Trifluorobenzene, molecular formula is C6H3F3, belongs to benzoxazole compound. In a document, author is Zhang, Mengting, introduce the new discover, Product Details of 372-38-3.

Benzoxazole-based nematic liquid crystals containing ethynyl and two lateral fluorine atoms with large birefringence

New kinds of heterocyclic mesogenic compounds containing benzoxazole, ethynyl, and laterally fluorinated phenyl groups, namely 2-[4-[2-[4-alkoxyphenyl]ethynyl]-2,3-difluorophenyl]benzoxazole derivatives (nPEDFPBx), are synthesized and evaluated. The compounds nPEDFPBx except nitro-substituted ones have enantiotropic nematic mesophases with mesophase ranges of 16-86 degrees C and 29-108 degrees C on heating and cooling, respectively. The results show that introduction of two lateral fluorine atoms into molecule results in enhanced nematic mesophase stability. Meanwhile, nPEDFPBx displays much higher birefringence (0.507-0.624) than common tolanebased liquid crystals, which is ascribed to its large pi-conjugated molecule composed of benzene, ethynyl, and benzoxazole mesogenic unit. The nPEDFPBx has a high potential to serve as a dopant for liquid crystal mixture. [GRAPHICS] .

Balanced chemical reaction does not necessarily reveal either the individual elementary reactions by which a reaction occurs or its rate law. In my other articles, you can also check out more blogs about 372-38-3. Product Details of 372-38-3.

Reference:
Benzoxazole – Wikipedia,
,Benzoxazole | C7H5NO – PubChem

Reactions catalyzed within inorganic and organic materials and at electrochemical interfaces commonly occur at high coverage and in condensed media, causing turnover rates to depend strongly on interfacial structure and composition, 5471-63-6, Name is 1,3-Diphenylisobenzofuran, SMILES is C1(C2=CC=CC=C2)=C3C=CC=CC3=C(C4=CC=CC=C4)O1, in an article , author is Tang, Jun, once mentioned of 5471-63-6, Recommanded Product: 1,3-Diphenylisobenzofuran.

New Approach for Controllable Synthesis of N-MnOx Microflowers and Their Superior Catalytic Performance for Benzoxazole Synthesis

Condensation of 2-amino-phenols with carboxylic acid derivatives has been practically used for the production of benzoxazoles, wherein the homogeneous catalytic system including strong acids and dangerous peroxides is generally employed. Herein, we report the novel approach for controlled synthesis of nitrogen-doped MnOx (denoted as N-MnO2, N-Mn5O8, and N-Mn3O4), by adjusting the heteroatom nitrogen amount, and uncover that the N-MnO2 catalyst as a sustainable and cost-effective heterogeneous catalyst exhibits high catalytic performance for condensation of 2-amino-phenols and o-phenylenediamine with alcohols into the corresponding benzoxazoles and benzimidazole, respectively. The N-MnO2 catalyst displays >99.9% yield for benzoxazole synthesis under room temperature and no decay (10 cycles), compared with the neglect activity (similar to 0%) for MnO2 catalysts. X-ray absorption spectroscopies and experimental studies uncovered that oxygen vacancies generated by heteroatom N doping play a key role for promoting intramolecular oxidative dehydrogenation of alcohol and 2-aminophenol derivatives to directly yield desired products. N-MnO2 catalyst rapidly oxidative dehydrogenated the reactants into corresponding benzoxazoles for 10 examples with >87.6% yields.

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Reference:
Benzoxazole – Wikipedia,
,Benzoxazole | C7H5NO – PubChem

Reactions catalyzed within inorganic and organic materials and at electrochemical interfaces commonly occur at high coverage and in condensed media, causing turnover rates to depend strongly on interfacial structure and composition, 120-21-8, Name is 4-Diethylaminobenzaldehyde, SMILES is O=CC1=CC=C(N(CC)CC)C=C1, in an article , author is Krause, Malwina, once mentioned of 120-21-8, SDS of cas: 120-21-8.

Synthesis and Tuberculostatic Activity Evaluation of Novel Benzazoles with Alkyl, Cycloalkyl or Pyridine Moiety

Compounds possessing benzimidazole system exhibit significant antituberculous activity. In order to examine how structure modifications affect tuberculostatic activity, a series of benzazole derivatives were synthesized and screened for their antitubercular activity. The compounds 1-20 were obtained by the reaction between 0-diamine, 0-aminophenol, or 0-aminothiophenol with carboxylic acids or thioamides. The newly synthesized compounds were characterized by IR, H-1-NMR, C-13-NMR spectra, and elemental analysis. Synthesized benzazoles were evaluated for their tuberculostatic activity toward Mycobacterium tuberculosis strains. Quantum chemical calculations were performed to study the molecular geometry and the electronic structure of benzimidazoles GK-151B, 4, 6, and benzoxazole 11, using the Gaussian 03W software (Gaussian, Inc., Wallingford, CT, USA). Three-dimensional structure of benzimidazoles 1-3, MC-9, and GK-151B was determined by ab initio calculation using Gamess- US software. The activity of the received benzimidazoles was moderate or good. All of the benzoxazoles and benzothiazoles demonstrated much lower activity. Benzoxazoles were less active by about 50 times, and benzothiazole by 100 times than the benzimidazole analogs. Quantum chemical calculations showed differences in the distribution of electrostatic potential in the benzazole system of benzimidazoles and benzoxazoles. Three-dimensional structure calculations revealed how the parity of the alkyl substituent at the C2 position impacts the activity. Benzimidazole system is essential for the antituberculosis activity that is associated with the presence of the imine nitrogen atom in N-1 position. Its replacement by an oxygen or sulfur atom results in a decrease of the activity. The parity of the alkyl substituent at the C-2 position also modifies the activity.

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Reference:
Benzoxazole – Wikipedia,
,Benzoxazole | C7H5NO – PubChem

One of the major reasons for studying chemical kinetics is to use measurements of the macroscopic properties of a system, such as the rate of change in the concentration of reactants or products with time. 120-21-8, Name is 4-Diethylaminobenzaldehyde, formurla is C11H15NO. In a document, author is Feng, Pengju, introducing its new discovery. HPLC of Formula: C11H15NO.

Copper-Catalyzed Direct C-H Bond Arylation of Benzoxazoles with Anilines

An efficient and easily managed protocol was developed for the synthesis of 2-aryl-substituted benzoxazoles by using a copper-catalyzed C-H arylation reaction between benzoxazole derivatives and insitu generated aryl diazonium salts. Under the optimized conditions, a wide variety of products were selectively obtained in moderate to good yields. Diphenylamine and 2,3-bipyridine were also obtained under the same reaction conditions by employing aniline and pyridin-3-amine, respectively, as the sole starting material.

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Reference:
Benzoxazole – Wikipedia,
,Benzoxazole | C7H5NO – PubChem

Synthetic Route of 540-37-4, Redox catalysis has been broadly utilized in electrochemical synthesis due to its kinetic advantages over direct electrolysis. The appropriate choice of redox mediator can avoid electrode passivation and overpotential. 540-37-4, Name is 4-Iodoaniline, SMILES is NC1=CC=C(I)C=C1, belongs to benzoxazole compound. In a article, author is Li, Xianglong, introduce new discover of the category.

Novel synthesis of high-molecular-weight prepolymer of poly(p-phenylene benzoxazole) in ionic liquids

Using ionic liquids (ILs) as the reaction solvent for the synthesis of prepolymer polyamide of poly(p-phenylene benzoxazole) (PBO) was investigated. The optimum condition of prepolymer preparation was determined in ILs. A series of 1,3-dialkylimidazolium ILs were used to be the reaction media of the polycondensation. The relationship between the molecular weight of prepolymer and the structure of ILs was analysed by changing the structure of the cation and species of anion of ILs. In order to prove the feasibility of the transformation, the prepolymer was used to prepare PBO in polyphosphoric acid media, and the conversion process was analyzed. The spinnability of the PBO solution was explored by the preparation of PBO fibers. The basic mechanical properties of PBO single fiber were tested. In a word, using 1,3-dialkylimidazolium ILs as the reaction solvents was feasible for the synthesis of high-molecular-weight PBO prepolymer, which could be a promising PBO preparation method.

Synthetic Route of 540-37-4, The reactant in an enzyme-catalyzed reaction is called a substrate. Enzyme inhibitors cause a decrease in the reaction rate of an enzyme-catalyzed reaction.I hope my blog about 540-37-4 is helpful to your research.

Reference:
Benzoxazole – Wikipedia,
,Benzoxazole | C7H5NO – PubChem

The reaction rate of a catalyzed reaction is faster than the reaction rate of the uncatalyzed reaction at the same temperature. Recommanded Product: 405-50-5, 405-50-5, Name is 2-(4-Fluorophenyl)acetic acid, SMILES is C1=C(C=CC(=C1)F)CC(O)=O, in an article , author is Jiao, Yang, once mentioned of 405-50-5.

Synthesis and properties of poly(benzoxazole imide)s derived from two isomeric diamines containing a benzoxazole moiety

Two isomeric diamine monomers, 2-(3-aminophenyl)benzo[d]oxazol-5-amine (2a) and 2-(3-aminophenyl)benzo[d]oxazol-6-amine (2b), were designed and synthesized. The corresponding novel series of poly(benzoxazole imide)s (PBOPIs) were prepared with commercial tetracarboxylic dianhydrides via thermal imidization. These series of PBOPIs showed great T(g)s ranging from 285 to 363 degrees C, excellent thermal stability when performed at 5% weight loss temperatures (T(d5%)s) of 510-564 degrees C in N-2 and good mechanical properties (tensile strengths of 103-126 MPa, tensile moduli of 2.9-3.7 GPa and elongations at break of 3.0-6.5%). Furthermore, controlled molecular weight (M-w) polymers PI-3a-PA and PI-3b-PA derived from 4,4 ‘-oxydiphthalic anhydride (ODPA) with 2a and 2b demonstrated good melt processability with minimum complex viscosities of 2258 and 3444 Pa center dot s at 420 degrees C and low melt viscosity ratios of 1.29 and 1.93 at 400 degrees C, respectively. The PI-b series showed higher T-g & T-d5% and lower transparency compared with the PI-a series due to the isomeric effect.

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Reference:
Benzoxazole – Wikipedia,
,Benzoxazole | C7H5NO – PubChem