Heterocyclic Building Blocks-Benzoxazole

Choi, Wonseok’s team published research in Organic Letters in 2015-07-02 | CAS: 145026-07-9

Synthesis of N-Imidoyl and N-Oxoimidoyl Sulfoximines from 1-Alkynes, N-Sulfonyl Azides, and Sulfoximines. Recommended basis is Sulfoximine, Bioisosteric. Products is: https://www.ambeed.com/products/1621962-30-8.html, 50578-18-2

1-Bromo-4-(S-methylsulfonimidoyl)benzene (BD336512) is a building block containing a sulfoximine group. Several CDK and ATR inhibitors have exemplified the utilization of the NH sulfoximine group as abioisostere for a sulfonamide group to overcome the main project hurdles of aqueous solubility, sulfonamide-mediated off-target activity and IP. Moreover, its NH group could be expediently further functionalized through Buchwald-Hartwig coupling reaction and multifarious nucleophilic reactions.. Recommended Products is: 4381-25-3 and 83730-53-4.

N-Imidoylation of sulfoximines is developed from a Cu-catalyzed three-component reaction from 1-alkynes, N-sulfonyl azides, and sulfoximines in THF at room temperature under air. In addition, N-oxoimidoylation of sulfoximines is accessed from a Cu-catalyzed three-component reaction from 1-alkynes, N-sulfonyl azides, and sulfoximines in THF at room temperature followed by a Cu-catalyzed oxidative reaction at 50 ¡ãC under air, producing N-oxoimidoyl sulfoximines.

Referemce:
Benzoxazole – Wikipedia,
Benzoxazole | C7H5NO – PubChem

Wang, Bao’s team published research in Molecules in 2020 | CAS: 145026-07-9

Sulfoximines-assisted Rh(III)-catalyzed C-H activation and intramolecular annulation for the synthesis of fused isochromeno-1,2-benzothiazines scaffolds under room temperature. Recommended basis is Sulfoximine, Bioisosteric. Products is: https://www.ambeed.com/products/1621962-30-8.html, 50578-18-2

A mild and facile Cp*Rh(III)-catalyzed C-H activation and intramol. cascade annulation protocol has been proposed for the furnishing of highly fused isochromeno-1,2-benzothiazines I (R1 = H, 2-Me, 2-F, 4-Br, 3-OMe, (CH2)4, etc.; R2 = Me, Et, Ph, Bn, etc.; R3 = H, 10-Me,10-OMe, 11-Cl, 11-F, etc.) scaffolds using S-phenylsulfoximides R4C6H4S(O)(=NH)(R2) and 4-diazoisochroman-3-imine II (R5 = H, 7-Me, 6-OMe, 7-OMe, 6-Cl, etc.) as substrates under room temperature This method features diverse substituents and functional groups tolerance and relatively mild reaction conditions with moderate to excellent yields. Addnl., retentive configuration of sulfoximides in the conversion has been verified.

Referemce:
Benzoxazole – Wikipedia,
Benzoxazole | C7H5NO – PubChem

Luan, Nannan’s team published research in Tetrahedron Letters in 2020-01-02 | CAS: 50578-18-2

PhI(OAc)2-mediated oxidative C-H sulfoximination of imidazopyridines under mild conditions. Recommended basis is Sulfoximine, Bioisosteric. Products is: https://www.ambeed.com/products/1621962-30-8.html, 145026-07-9

1-Iminotetrahydrothiophene 1-oxide (BD00963737) is a building block containing a sulfoximine group. Several CDK and ATR inhibitors have exemplified the utilization of the NH sulfoximine group as abioisostere for a sulfonamide group to overcome the main project hurdles of aqueous solubility, sulfonamide-mediated off-target activity and IP. Moreover, its NH group could be expediently further functionalized through Buchwald-Hartwig coupling reaction and multifarious nucleophilic reactions.. Recommended Products is: 4381-25-3 and 83730-53-4.

A facile protocol for direct oxidative C-N bond coupling of unactivated imidazo[1,2-a]pyridines with NH-sulfoximines was disclosed using sulfoximines as the nitrogen sources in the presence of (diacetoxy)iodobenzene (PhI(OAc)2). The reaction proceeded smoothly under air without any metal catalyst to give a series of C-3 sulfoximidoyl-functionalized imidazo[1,2-a]pyridines products regioselectively.

Referemce:
Benzoxazole – Wikipedia,
Benzoxazole | C7H5NO – PubChem

Tavallali, Vahid’s team published research in Scientia Horticulturae (Amsterdam, Netherlands) in 2022-09-20 | CAS: 483-76-1

Modifications in Lemongrass (Cymbopogon spp.) in response to green synthesized nano-selenium complex. Recommended basis is Cadinene. Products is: https://www.ambeed.com/products/189165-77-3.html, 51905-84-1

1. Trivial name: delta-Cadinene.
2. It’s mainly derived from flue-cured tobacco, burley tobacco and flavoured tobacco, it has a strong aroma and a good fixing effect, suitable for perfume, cosmetics, can also be used in wine, cigarettes, and toothpaste.
. Recommended Products is: 29350-73-0 and 51905-84-1.

Selenium nanoparticles (Se-NPs) have different applications in various technologies due to their individual properties. In order to investigate the impacts of different concentrations of a green-synthesized selenium nano-complex (0, 20, 40, 60, and 80 mg L-1) on the chem. composition, antioxidant capacity and antimicrobial activity of lemongrass essential oil (EO), an experiment was designed as a completely randomized design (CRD) with four replications. The application of 40 mg L-1 selenium nano-complex caused the highest EO yield (3.96 ¡À 0.09%). The dominant compounds in EO, geranial (44.12 ¡À 1.22%) and neral (32.53 ¡À 1.08%), were achieved by the application of 60 mg L-1 selenium nano-complex. HPLC anal. indicated that the extracts were rich in 5-o-cafeoylquinic acid, luteolin 6-c-pentosyl-8-c-pentoside, and luteolin 2-o-deoxyhexosyl-6-c-glucoside. The extracts of lemongrass plants treated with 40 and 60 mg L-1 selenium nano-complex achieved the highest amount of 5-o-cafeoylquinic acid (25.29¡À1.31 and 24.16¡À1.26 ¦Ìg mL-1, resp.). The highest antioxidant capacity was observed in the 40 mg L-1 selenium nano-complex treated plants. The min. inhibitory concentration (MIC) of EO derived from the 60 mg L-1 selenium nano-complex treated lemongrass for Salmonella typhimurium, Escherichia coli, Staphylococcus aureus, Bacillus subtilis, Aspergillus niger and Candida albicans was 0.63¡À0.03, 1.84¡À0.1, 1.05¡À0.05, 0.008¡À0.01, 0.6¡À0.01 and 0.1¡À0.01 mg mL-1, resp. It is expected that the selenium nano-complex would find a wide range of applications in medicine for its antioxidant and antimicrobial properties. It may also be applied to medicinal plants to enhance the quality and quantity of EOs.

Referemce:
Benzoxazole – Wikipedia,
Benzoxazole | C7H5NO – PubChem

Qin, Yu-Liang’s team published research in Food Control in 2023-03-31 | CAS: 483-76-1

The effect of volatile compounds of Syzygium aromaticum flower buds against Aspergillus flavus growth on wheat grain at postharvest stage. Recommended basis is Cadinene. Products is: https://www.ambeed.com/products/189165-77-3.html, 51905-84-1

Reducing the postharvest loss of cereal grains caused by deleterious fungi is critically important for the grain supply chain. Exploring antifungal constituents of plant volatile organic compounds (PVOCs) could promote the development of natural gaseous fungicides in controlling the decay of postharvest grains. In this study, PVOCs were extracted from clove (Syzygium aromaticum L.) buds and the primary constituents thereof were investigated for their effect on Aspergillus flavus growth in media postharvest grains. Fumigation with clove buds volatiles effectively inhibited A. flavus proliferation in 20% moisture wheat grains under simulated storage conditions. Gas chromatog.-mass spectrometry anal. revealed that eugenol and caryophyllene were the two main constituents of clove bud volatiles (49.80% and 36.68%, resp.). An antifungal assay demonstrated that eugenol was responsible for the antifungal activity of clove bud volatiles against A. flavus. Eugenol can completely inhibit A. flavus growth at 0.12 and 0.40 ¦ÌL/mL in vapor phase fumigation and liquid contact, resp. The proliferation of A. flavus in 20% moisture wheat grains was completely controlled after fumigation with 600 ¦ÌL/L eugenol vapor. Eugenol treatment can damage the membrane integrity of A. flavus mycelia, resulting in increased intracellular electrolyte leakage. The 38 metabolites in A. flavus hyphae exposed to 0.40 ¦ÌL/mL eugenol were markedly differentially expressed and principally involved in the biosynthesis of glycerophospholipids, linoleic acid metabolism, fatty acid metabolism, sugar metabolism, and ATP-binding cassette transporters. Eugenol also causes phosphatidylserine eversion of the plasma membrane, increased reactive oxygen species, decreased ATP production, and damaged DNA in A. flavus. We propose that eugenol treatment can disrupt cell membrane integrity, fatty acid ¦Â-oxidation, and induce apoptosis in A. flavus. This study demonstrated the potential application of clove bud volatile organic compounds as biofumigants for postharvest grain management and provided new insights into the antifungal mechanism of the main constituents against A. flavus growth.

Referemce:
Benzoxazole – Wikipedia,
Benzoxazole | C7H5NO – PubChem

Ma, Ding’s team published research in Advanced Synthesis & Catalysis in 2021-03-03 | CAS: 1621962-30-8

Palladium-Catalyzed Carbonylation in the Synthesis of N-Ynonylsulfoximines. Recommended basis is Sulfoximine, Bioisosteric. Products is: https://www.ambeed.com/products/50578-18-2.html, 145026-07-9

4-(S-Methylsulfonimidoyl)benzonitrile (BD00975057) is a building block containing a sulfoximine group. Several CDK and ATR inhibitors have exemplified the utilization of the NH sulfoximine group as abioisostere for a sulfonamide group to overcome the main project hurdles of aqueous solubility, sulfonamide-mediated off-target activity and IP. Moreover, its NH group could be expediently further functionalized through Buchwald-Hartwig coupling reaction and multifarious nucleophilic reactions.. Recommended Products is: 4381-25-3 and 83730-53-4.

Palladium-catalyzed carbonylation reactions with Cr(CO)6 as carbonyl source are key for the preparation of N-ynonylsulfoximines RCCC(O)N=S(O)(R1)(R2) (R = Ph, cyclohexyl, 2-fluorophenyl, etc.; R1 = Ph, 3-methoxyphenyl, 2-bromophenyl, etc.; R2 = Me, Ph) and N-(8-oxo-8-thiatricyclo[7.4.0.0(2,7)]trideca-1(13),2,4,6,9,11-hexaen-8-ylidene)-3-phenylprop-2-ynamide from NH-sulfoximines HN=S(O)(R1)(R2), 8-thiatricyclo[7.4.0.0(2,7)]trideca-1(13),2,4,6,9,11-hexaen-8-one and bromoalkynes RCCBr. The couplings proceed at room temperature with a wide range of substrate combinations affording the corresponding products in good yields.

Palladium-Catalyzed Carbonylation in the Synthesis of N-Ynonylsulfoximines. Recommended basis is Sulfoximine, Bioisosteric. Products is: https://www.ambeed.com/products/50578-18-2.html, 145026-07-9

Referemce:
Benzoxazole – Wikipedia,
Benzoxazole | C7H5NO – PubChem

Wang, Han’s team published research in Journal of Organic Chemistry in 2017-11-17 | CAS: 145026-07-9

Sulfoximidoyl-Containing Hypervalent Iodine(III) Reagents: 1-Sulfoximidoyl-1,2-benziodoxoles. Recommended basis is Sulfoximine, Bioisosteric. Products is: https://www.ambeed.com/products/1621962-30-8.html, 50578-18-2

Treatment of NH-sulfoximines with pseudocyclic benziodoxole triflate results in N-I bond formation leading to a new type of sulfoximidoyl-containing hypervalent iodine(III) reagents in high yields. Degradation studies revealed a pronounced stability in both the solid state and in solution

Referemce:
Benzoxazole – Wikipedia,
Benzoxazole | C7H5NO – PubChem

Qiu, Pan’s team published research in Organic Letters in 2022-04-15 | CAS: 4381-25-3

Visible-Light-Induced N-Acylation of Sulfoximines. Recommended basis is Sulfoximine, Bioisosteric. Products is: https://www.ambeed.com/products/50578-18-2.html, 145026-07-9

(S-Methylsulfonimidoyl)benzene (BD302898) is a building block containing a sulfoximine group. Several CDK and ATR inhibitors have exemplified the utilization of the NH sulfoximine group as abioisostere for a sulfonamide group to overcome the main project hurdles of aqueous solubility, sulfonamide-mediated off-target activity and IP. Moreover, its NH group could be expediently further functionalized through Buchwald-Hartwig coupling reaction and multifarious nucleophilic reactions.. Recommended Products is: 83730-53-4 and 1621962-30-8.

A metal-, base- and additive-free N-acylation of sulfoximines was developed under mild conditions using organic photoredox catalyst. This green strategy featured broad substrate scope, good compatibility with air and high yields (up to 96%). It could be further applied to amino acid modifications and ¦Á-keto N-acyl sulfoximine synthesis without any complicated transformations or operations.

Visible-Light-Induced N-Acylation of Sulfoximines. Recommended basis is Sulfoximine, Bioisosteric. Products is: https://www.ambeed.com/products/50578-18-2.html, 145026-07-9

Referemce:
Benzoxazole – Wikipedia,
Benzoxazole | C7H5NO – PubChem

Pirwerdjan, Ramona’s team published research in Organic Letters in 2016-07-15 | CAS: 145026-07-9

Exploring the Reactivity of N-Alkynylated Sulfoximines: Acid-Catalyzed Cyclizations. Recommended basis is Sulfoximine, Bioisosteric. Products is: https://www.ambeed.com/products/1621962-30-8.html, 50578-18-2

N-Alkynylated sulfoximines undergo acid-promoted cyclization processes under mild reaction conditions. The transformations proceed in short reaction times affording sulfoximidoyl-functionalized naphtho[2,1-b]thiophenes or pyrrolo[1,2-a]quinolines in up to excellent yields.

Referemce:
Benzoxazole – Wikipedia,
Benzoxazole | C7H5NO – PubChem

Radzhabov, G. K.’s team published research in Pharmaceutical Chemistry Journal in 2022-08-31 | CAS: 483-76-1

Variability of the Constituent Composition of Achillea millefolium Essential Oils in the Wild Flora of Dagestan. Recommended basis is Cadinene. Products is: https://www.ambeed.com/products/189165-77-3.html, 51905-84-1

The variability of the chem. composition of the aerial part of common yarrow (Achillea millefolium L.) was studied as a function of its environmental growth conditions. Samples of four populations of A. millefolium growing wild at various altitudes (1150, 1500, 1700, and 2450 m) above sea level were collected. Their essential oils were obtained by hydrodistillation followed by a determination of their chem. compositions by chromatog.-mass-spectrometry. Anal. results showed that the yield of essential oil from the plants depended on the habitat and varied from 0.06 to 0.16 mL/100 g. The composition of the essential oil of A. millefolium comprised 61 constituents, of which 47 were identified, the main group being monoterpenes and their derivatives The yield of essential oil and its composition were controlled by linear effects of several abiotic factors related to the altitude gradient.

Referemce:
Benzoxazole – Wikipedia,
Benzoxazole | C7H5NO – PubChem