Heterocyclic Building Blocks-Benzoxazole

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Discovery of 4-Benzyloxybenzo[ d]isoxazole-3-amine Derivatives as Highly Selective and Orally Efficacious Human Sphingomyelin Synthase 2 Inhibitors that Reduce Chronic Inflammation in db/ db Mice

Sphingomyelin synthase 2 (SMS2) is a promising therapeutic target for several chronic inflammation-associated diseases, including atherosclerosis, fatty liver, and insulin resistance. Herein, we report the identification of 4-benzyloxybenzo[d]isoxazole-3-amine derivatives as potent and highly selective SMS2 inhibitors through a conformational restriction strategy. After systematic structural modifications, several compounds with high selectivity and good potency in vitro were selected for further evaluation. Compound 15w demonstrated good pharmacokinetics (oral bioavailability, F = 56%) in vivo and has an inhibitory potency against sphingomyelin synthase activity when Institute of Cancer Research mice are provided with an oral dose of this compound. In addition, compound 15w attenuated chronic inflammation significantly in db/db mice after oral dosing for 6 weeks.

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Benzoxazole – Wikipedia,
Benzoxazole | C7H5NO – PubChem

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Exploring Steric Effects of Zinc Complexes Bearing Achiral Benzoxazolyl Aminophenolate Ligands in Isoselective Polymerization of rac-Lactide

A series of tridentate achiral benzoxazolyl-based aminophenolate zinc complexes, LZnN(SiMe3)2 (L = 2-{[benzoxazoly-CH2N(R3)-]CH2}-6-R1-4-R2-C6H2O, R1 = R2 = Cl, R3 = Bn (1); R1 = R2 = tBu, R3 = Bn (2); R1 = trityl, R2 = Me: R3 = Bn (3); R3 = phenethyl (4); R3 = 3-methylbutyl (7); R3 = n-hexyl (8); R3 = cyclopentyl (9); R3 = cyclooctyl (11); R3 = 1-adamantyl (12)), was synthesized via the reactions of Zn[N(SiMe3)2]2 and 1 equiv of the corresponding aminophenol proligands. All of the complexes were obtained as racemates, and the X-ray diffraction studies confirmed the monomeric structures of typical complexes 11 and 12, where the metal center is tetra-coordinated by three donors of the aminophenolate ligand and one silylamido group. All of the complexes proved to be efficient initiators for the ring-opening polymerization of rac-lactide (rac-LA) at ambient temperature, and the polymerizations were better controlled in the presence of 2-propanol. The substituents on the ortho-position of the phenoxide unit of the ligand and the skeleton nitrogen atom show significant influences on the stereoselectivity of the corresponding complex toward the polymerization of rac-LA, leading to the production of heterotactic biased polylactide (PLA) by complexes 1 and 2 (Pm = 0.40-0.44) and moderately to highly isotactic PLA by complexes 3-12 (Pm = 0.74-0.89). Detailed mechanism studies and microstructure analysis of typical PLA samples revealed that these zinc initiators afforded isotactic stereoblock PLAs via a chain-end control mechanism, and there is no obvious polymer exchange process during the polymerization process.

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Benzoxazole – Wikipedia,
Benzoxazole | C7H5NO – PubChem

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In vitro inhibitory effects of esculetin on human liver cytochrome P450 enzymes

Esculetin (ESC), a derivative of coumarin, possesses a number of pharmacological activities. Cytochrome P450 (CYP) enzymes play a vital role in the biotransformation of xenobiotics; its activity di-rectly affects the bioavailability of the drugs. Therefore, should be paid attention in the effect of ESC on the activity of CYPs. The effects of ESC on eight human liver CYP isoforms (i.e., 1A2, 3A4, 2A6, 2E1, 2D6, 2C9, 2C19 and 2C8) were investigated in vitro using human liver microsomes (HLMs), and the enzyme kinetic parameters were calculated. ESC inhibited the activity of CYP3A4, CYP2E1 and CYP1A2, with IC50 values of 15.01, 23.22 and 19.42 muM, respectively, but other CYPs were not affected. The inhibition of CYP3A4 by ESC was best fitted in a non-competitive manner, with the Ki value of 7.53 muM. Whereas, ESC competitively inhibited the activity of CYP2E1 and CYP1A2, with Ki values of 11.13 and 9.19 muM, re-spectively. In addition, ESC is a time dependent inhibitor for CYP3A4 with KI/Kinact value of 9.52/0.061 min?1muM?1. The in vitro studies of ESC with CYP isoforms indicate that ESC has the potential to cause pharmacokinetic drug interactions with other co-administered drugs metabolized by CYP3A4, CYP2E1 and CYP1A2. Further clinical studies are needed to evaluate the significance of this interaction.

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Benzoxazole – Wikipedia,
Benzoxazole | C7H5NO – PubChem

Related Products of 64037-16-7, Chemistry is the experimental science by definition. We want to make observations to prove hypothesis. For this purpose, we perform experiments in the lab. 64037-16-7, Name is 5-Nitrobenzo[d]oxazol-2-amine,introducing its new discovery.

REACTION OF 2-AMINOBENZOXAZOLES WITH COMPOUNDS WITH ACTIVATED MULTIPLE BONDS

The reaction of 2-aminobenzoxazoles with activated alkenes of the acrylic acid type and its derivatives and methyl vinyl ketone proceeds in the presence of basic catalysts to give products of mono- and diaddition at the exocyclic nitrogen atom.The reaction of 5(6)-substituted 2-aminobenzoxazoles with esters of propyl and acetylenedicarboxylic acids in the absence of catalysts leads to the production of condensed 2-oxopyrimidines.The effect of substituents and the reaction conditions on the course of the process was investigated.

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Benzoxazole – Wikipedia,
Benzoxazole | C7H5NO – PubChem

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8-[3-Amino-piperidin-1-yl]-xanthines, their preparation and their use as pharmaceutical composition

The present invention relates to substituted xanthines of general formula wherein R1 and R2 are defined as in the claims, the tautomers, the stereoisomers, the mixtures thereof, and the salts thereof, which have valuable pharmacological properties, particularly an inhibiting effect on the activity of the enzyme dipeptidylpeptidase-IV (DPP-IV).

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Benzoxazole – Wikipedia,
Benzoxazole | C7H5NO – PubChem

One of the major reasons for studying chemical kinetics is to use measurements of the macroscopic properties of a system, Safety of Benzo[d]oxazol-2-amine, such as the rate of change in the concentration of reactants or products with time.In a article, mentioned the application of 4570-41-6, Name is Benzo[d]oxazol-2-amine, molecular formula is C7H6N2O

2-Benzamido-N-(1H-benzo[d]imidazol-2-yl)thiazole-4-carboxamide derivatives as potent inhibitors of CK1delta/epsilon

In this study we identified two heterocyclic compounds (5 and 6) as potent and specific inhibitors of CK1delta (IC50 = 0.040 and 0.042 muM, respectively). Whereas compound 5 exhibited fivefold higher affinity towards CK1delta than to CK1epsilon (IC50 CK1epsilon = 0.199 muM), compound 6 also inhibited CK1epsilon (IC50 = 0.0326 muM) in the same range as CK1delta. Selected compound 5 was screened over 442 kinases identifying 5 as Ahighly potent and selective inhibitor of CK1delta. X-ray analysis of 5 bound to CK1delta demonstrated its binding mode. In addition, characterization of 5 and 6 in Acell biological approach revealed the ability of both compounds to inhibit proliferation of tumor cell lines in Adose and cell line specific manner. In summary, our optimizations lead to the development of new highly selective CK1delta and epsilon specific inhibitors with biological activity.

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Benzoxazole – Wikipedia,
Benzoxazole | C7H5NO – PubChem

Chemistry is an experimental science, and the best way to enjoy it and learn about it is performing experiments. SDS of cas: 208772-23-0. Introducing a new discovery about 208772-23-0, Name is Benzo[d]oxazole-4-carboxylic acid

2-ALKYLBENZOXAZOLE CARBOXAMIDES AS 5HT3 MODULATORS

Compounds of formulae I and II: [image] are disclosed as 5-HT3 inhibitors. Those compounds are useful in treating CINV, IBS-D and other diseases and conditions.

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Benzoxazole – Wikipedia,
Benzoxazole | C7H5NO – PubChem

Chemistry is an experimental science, and the best way to enjoy it and learn about it is performing experiments. Product Details of 41014-43-1. Introducing a new discovery about 41014-43-1, Name is 2-(Chloromethyl)benzo[d]oxazole

Inhibitors of HIV reverse transcriptase

Novel aminopyridones inhibit HIV reverse transcriptase, and are useful in the prevention or treatment of infection by HIV and the treatment of AIDS, either as compounds, pharmaceutically acceptable salts, pharmaceutical composition ingredients, whether or not in combination with other antivirals, anti-infectives, immunomodulators, antibiotics or vaccines. Methods of treating AIDS and methods of preventing or treating infection by HIV are also described.

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Benzoxazole – Wikipedia,
Benzoxazole | C7H5NO – PubChem

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AMIDO COMPOUNDS

Compounds of the formula 1: or pharmaceutically acceptable salts thereof, wherein the variables are as defined herein. Also disclosed are methods of making the compounds and using the compounds for treatment of diseases associated with the P2X7 purinergic receptor.

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Benzoxazole – Wikipedia,
Benzoxazole | C7H5NO – PubChem

One of the major reasons for studying chemical kinetics is to use measurements of the macroscopic properties of a system, SDS of cas: 1750-45-4, such as the rate of change in the concentration of reactants or products with time.In a article, mentioned the application of 1750-45-4, Name is 5-Chloro-6-hydroxybenzo[d]oxazol-2(3H)-one, molecular formula is C7H4ClNO3

A liquid?chromatography-tandem mass spectrometry analysis of nine cytochrome P450 probe drugs and their corresponding metabolites in human serum and urine

Cocktail phenotyping using specific probe drugs for cytochrome P450 (CYP) enzymes provides information on the real-time activity of multiple CYPs. We investigated different sample preparation techniques and validated a liquid?chromatography-tandem mass spectrometry (LC-MS/MS) method with simple protein precipitation for the analysis of nine CYP probe drugs and their metabolites in human serum and urine. Specific CYP probe drugs (melatonin, CYP1A2; nicotine, CYP2A6; bupropion, CYP2B6; repaglinide, CYP2C8; losartan, CYP2C9; omeprazole, CYP2C19 and CYP3A4; dextromethorphan, CYP2D6; chlorzoxazone, CYP2E; midazolam, CYP3A4) and their main metabolites, with the exception of 3?-hydroxyrepaglinide, were quantified in human serum and urine using the developed LC-MS/MS method. The analytical method was fully validated showing high selectivity, linearity, acceptable accuracy (85?115?%) and precision (2?19?%) and applied to a pharmacokinetic study in four healthy volunteers after oral administration of drugs given as a cocktail. All probe drugs and their metabolites (totally 19 analytes) were detected and quantified from human serum and urine over the time range of 1 to 6?h after oral administration. Therefore, the proposed method is applicable for drug interaction and CYP phenotyping studies utilizing?a cocktail approach. [Figure not available: see fulltext.]

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Benzoxazole – Wikipedia,
Benzoxazole | C7H5NO – PubChem