Zou, Ya’s team published research in European Journal of Organic Chemistry in 2015 | CAS: 145026-07-9

CuI-Mediated ¦Á-Ketoacylation of Sulfoximines under Solvent-Free Conditions. Recommended basis is Sulfoximine, Bioisosteric. Products is: https://www.ambeed.com/products/1621962-30-8.html, 50578-18-2

1-Bromo-4-(S-methylsulfonimidoyl)benzene (BD336512) is a building block containing a sulfoximine group. Several CDK and ATR inhibitors have exemplified the utilization of the NH sulfoximine group as abioisostere for a sulfonamide group to overcome the main project hurdles of aqueous solubility, sulfonamide-mediated off-target activity and IP. Moreover, its NH group could be expediently further functionalized through Buchwald-Hartwig coupling reaction and multifarious nucleophilic reactions.. Recommended Products is: 4381-25-3 and 83730-53-4.

A series of desired 2-oxo-2-arylacetyl sulfoximines RC(O)C(O)N=S(O)R1R2 [R = C(CH3)3, 3,4-Cl2C6H3, thiophen-2-yl, naphth-2-yl, etc.; R1 = Me, Et, i-Pr, Ph; R2 = C6H5, 2-ClC6H4, 4-H3COC6H4, etc.; R1R2 = -(CH2)4-] were successfully synthesized in good to excellent yields (up to 93%) under solvent-free conditions using aryl ethanones RC(O)CH3 and NH-sulfoximines R1R2S(O)=NH. The unprecedented protocol requires no extra solvents, bases, or additives and demonstrates outstanding compatibility with assorted functional groups (up to 27 examples). A plausible double catalytic cycle mechanism involving elemental iodine and copper is proposed; in-situ generated aryl-¦Á-iodo-ethanone and a sulfoximine-liganded-CuII intermediate play important roles in C(sp3)-N coupling. The postulated mechanism is inspired by key exptl. investigations detailed here.

CuI-Mediated ¦Á-Ketoacylation of Sulfoximines under Solvent-Free Conditions. Recommended basis is Sulfoximine, Bioisosteric. Products is: https://www.ambeed.com/products/1621962-30-8.html, 50578-18-2

Referemce:
Benzoxazole – Wikipedia,
Benzoxazole | C7H5NO – PubChem

Xu, Hui-Bei’s team published research in Organic Letters in 2020-03-06 | CAS: 4381-25-3

Iridium(III)-Catalyzed C-H Amidation/Cyclization of NH-Sulfoximines with N-Alkoxyamides: Formation of Thiadiazine-1-Oxides. Recommended basis is Sulfoximine, Bioisosteric. Products is: https://www.ambeed.com/products/50578-18-2.html, 145026-07-9

(S-Methylsulfonimidoyl)benzene (BD302898) is a building block containing a sulfoximine group. Several CDK and ATR inhibitors have exemplified the utilization of the NH sulfoximine group as abioisostere for a sulfonamide group to overcome the main project hurdles of aqueous solubility, sulfonamide-mediated off-target activity and IP. Moreover, its NH group could be expediently further functionalized through Buchwald-Hartwig coupling reaction and multifarious nucleophilic reactions.. Recommended Products is: 83730-53-4 and 1621962-30-8.

Synthesis of thiadiazine-1-oxide derivatives I [R1 = H, 4-Me, 3-OMe, etc.; R2 = i-Pr, 2-thienyl, Ph, etc.; R3 = 2-thienyl, Ph, 2-naphthyl, etc.] via Ir(III)-catalyzed C-H activation/cyclization of NH-sulfoximines with N-alkoxyamides as amidation reagents was developed. This one-pot cascade protocol tolerated diverse functional groups and readily constructed various heterocyclic frameworks in moderate to good yield.

Iridium(III)-Catalyzed C-H Amidation/Cyclization of NH-Sulfoximines with N-Alkoxyamides: Formation of Thiadiazine-1-Oxides. Recommended basis is Sulfoximine, Bioisosteric. Products is: https://www.ambeed.com/products/50578-18-2.html, 145026-07-9

Referemce:
Benzoxazole – Wikipedia,
Benzoxazole | C7H5NO – PubChem

Baranwal, Siddharth’s team published research in Tetrahedron Letters in 2020-07-02 | CAS: 145026-07-9

Copper catalyzed N-arylation of sulfoximines with aryldiazonium salts in the presence of DABCO under mild conditions. Recommended basis is Sulfoximine, Bioisosteric. Products is: https://www.ambeed.com/products/1621962-30-8.html, 50578-18-2

1-Bromo-4-(S-methylsulfonimidoyl)benzene (BD336512) is a building block containing a sulfoximine group. Several CDK and ATR inhibitors have exemplified the utilization of the NH sulfoximine group as abioisostere for a sulfonamide group to overcome the main project hurdles of aqueous solubility, sulfonamide-mediated off-target activity and IP. Moreover, its NH group could be expediently further functionalized through Buchwald-Hartwig coupling reaction and multifarious nucleophilic reactions.. Recommended Products is: 4381-25-3 and 83730-53-4.

N-Arylation of sulfoximines with aryldiazonium tetrafluoroborates was demonstrated in the presence of copper chloride and DABCO. A wide range of aryl and alkyl sufoximines were participated in the coupling reaction with different aryldiazonim salts bearing electron donating and withdrawing groups and provided the desired products in 67-88% yields. The reaction proceeded through a radical mechanism.

Copper catalyzed N-arylation of sulfoximines with aryldiazonium salts in the presence of DABCO under mild conditions. Recommended basis is Sulfoximine, Bioisosteric. Products is: https://www.ambeed.com/products/1621962-30-8.html, 50578-18-2

Referemce:
Benzoxazole – Wikipedia,
Benzoxazole | C7H5NO – PubChem

Das, Prasenjit’s team published research in Chemistry – An Asian Journal in 2020-03-15 | CAS: 4381-25-3

Palladium-Catalyzed Decarboxylative ortho-C(sp2)-H Aroylation of N-Sulfoximine Benzamides at Room Temperature. Recommended basis is Sulfoximine, Bioisosteric. Products is: https://www.ambeed.com/products/50578-18-2.html, 145026-07-9

(S-Methylsulfonimidoyl)benzene (BD302898) is a building block containing a sulfoximine group. Several CDK and ATR inhibitors have exemplified the utilization of the NH sulfoximine group as abioisostere for a sulfonamide group to overcome the main project hurdles of aqueous solubility, sulfonamide-mediated off-target activity and IP. Moreover, its NH group could be expediently further functionalized through Buchwald-Hartwig coupling reaction and multifarious nucleophilic reactions.. Recommended Products is: 83730-53-4 and 1621962-30-8.

A palladium-catalyzed method for the decarboxylative ortho C-H acylation of N-sulfoximine benzamides was developed at room temperature The catalytic method enabled easy access to various functionalized 2-aroylarom. carboxylic acid derivatives in good isolated yields. Based on our mechanistic studies, a Pd(II)/Pd(IV) catalytic cycle that involved aroyl radical intermediate was proposed for the reaction.

Palladium-Catalyzed Decarboxylative ortho-C(sp2)-H Aroylation of N-Sulfoximine Benzamides at Room Temperature. Recommended basis is Sulfoximine, Bioisosteric. Products is: https://www.ambeed.com/products/50578-18-2.html, 145026-07-9

Referemce:
Benzoxazole – Wikipedia,
Benzoxazole | C7H5NO – PubChem

Luan, Nannan’s team published research in Tetrahedron Letters in 2020-01-02 | CAS: 145026-07-9

PhI(OAc)2-mediated oxidative C-H sulfoximination of imidazopyridines under mild conditions. Recommended basis is Sulfoximine, Bioisosteric. Products is: https://www.ambeed.com/products/1621962-30-8.html, 50578-18-2

1-Bromo-4-(S-methylsulfonimidoyl)benzene (BD336512) is a building block containing a sulfoximine group. Several CDK and ATR inhibitors have exemplified the utilization of the NH sulfoximine group as abioisostere for a sulfonamide group to overcome the main project hurdles of aqueous solubility, sulfonamide-mediated off-target activity and IP. Moreover, its NH group could be expediently further functionalized through Buchwald-Hartwig coupling reaction and multifarious nucleophilic reactions.. Recommended Products is: 4381-25-3 and 83730-53-4.

A facile protocol for direct oxidative C-N bond coupling of unactivated imidazo[1,2-a]pyridines with NH-sulfoximines was disclosed using sulfoximines as the nitrogen sources in the presence of (diacetoxy)iodobenzene (PhI(OAc)2). The reaction proceeded smoothly under air without any metal catalyst to give a series of C-3 sulfoximidoyl-functionalized imidazo[1,2-a]pyridines products regioselectively.

PhI(OAc)2-mediated oxidative C-H sulfoximination of imidazopyridines under mild conditions. Recommended basis is Sulfoximine, Bioisosteric. Products is: https://www.ambeed.com/products/1621962-30-8.html, 50578-18-2

Referemce:
Benzoxazole – Wikipedia,
Benzoxazole | C7H5NO – PubChem

Bellemin-Laponnaz, Stephane’s team published research in Polyhedron in 29 | CAS: 1207294-92-5

Polyhedron published new progress about 1207294-92-5. 1207294-92-5 belongs to benzoxazole, auxiliary class Achiral NHCs Ligands, name is 5,7-Di-tert-butyl-3-phenylbenzo[d]oxazol-3-ium tetrafluoroborate, and the molecular formula is C21H26BF4NO, Quality Control of 1207294-92-5.

Bellemin-Laponnaz, Stephane published the artcileSynthesis of N,O-heterocyclic carbene and coordination to rhodium(I) and copper(I), Quality Control of 1207294-92-5, the publication is Polyhedron (2010), 29(1), 30-33, database is CAplus.

5,7-Di-tert-butyl-3-Ph benzoxazolium tetrafluoroborate 1 could be prepared by simple reaction of the corresponding aminophenol with tri-Et orthoformate under acidic conditions. Both rhodium(I) and copper(I) complexes with benzoxazol-2-ylidene ligand were then efficiently synthesized in a straightforward and smooth manner involving the reaction of benzoxazolium salt 1 with metal precursor and an external base. The complexes were fully characterized and used in metal-catalyzed hydrosilylation of ketones, where they showed poor catalytic activity, presumably due to low stability of the complexes under those conditions.

Polyhedron published new progress about 1207294-92-5. 1207294-92-5 belongs to benzoxazole, auxiliary class Achiral NHCs Ligands, name is 5,7-Di-tert-butyl-3-phenylbenzo[d]oxazol-3-ium tetrafluoroborate, and the molecular formula is C21H26BF4NO, Quality Control of 1207294-92-5.

Referemce:
https://en.wikipedia.org/wiki/Benzoxazole,
Benzoxazole | C7H5NO – PubChem

Liao, Zhehui’s team published research in Journal of Organic Chemistry in 86 | CAS: 1239015-11-2

Journal of Organic Chemistry published new progress about 1239015-11-2. 1239015-11-2 belongs to benzoxazole, auxiliary class TOX Ligands, name is (3aS,3a’S,3a”S,8aR,8a’R,8a”R)-2,2′,2″-(Propane-1,2,2-triyl)tris(8,8a-dihydro-3aH-indeno[1,2-d]oxazole), and the molecular formula is C33H29N3O3, Category: benzoxazole.

Liao, Zhehui published the artcileCopper-Catalyzed Asymmetric Synthesis of Bicyclo[3.n.1]alkenones, Category: benzoxazole, the publication is Journal of Organic Chemistry (2021), 86(7), 5388-5400, database is CAplus and MEDLINE.

A series of highly strained bicyclo[3.n.1]alkenones such as I (R = Me, Et, i-Pr) have been successfully constructed in good to excellent enantioselectivities and moderate to good yields by copper-catalyzed formal [3+3] cycloaddition reaction of 2-oxocycloalkanecarboxylates and aryl vinyl ketones or arylethenyl vinyl ketones via nonracemic oxoalkyl-substituted oxocycloalkanecarboxylates such as II (R = Me, Et, i-Pr). The cycloadducts were selectively converted into various valuable bicyclic ring systems holding considerable potential for the construction of natural and bioactive compounds containing a [3.n.1] moiety.

Journal of Organic Chemistry published new progress about 1239015-11-2. 1239015-11-2 belongs to benzoxazole, auxiliary class TOX Ligands, name is (3aS,3a’S,3a”S,8aR,8a’R,8a”R)-2,2′,2″-(Propane-1,2,2-triyl)tris(8,8a-dihydro-3aH-indeno[1,2-d]oxazole), and the molecular formula is C33H29N3O3, Category: benzoxazole.

Referemce:
https://en.wikipedia.org/wiki/Benzoxazole,
Benzoxazole | C7H5NO – PubChem

Huang, Ke-Xin’s team published research in Organic Letters in 23 | CAS: 1239015-11-2

Organic Letters published new progress about 1239015-11-2. 1239015-11-2 belongs to benzoxazole, auxiliary class TOX Ligands, name is (3aS,3a’S,3a”S,8aR,8a’R,8a”R)-2,2′,2″-(Propane-1,2,2-triyl)tris(8,8a-dihydro-3aH-indeno[1,2-d]oxazole), and the molecular formula is C33H29N3O3, Category: benzoxazole.

Huang, Ke-Xin published the artcileAsymmetric Synthesis of 3-Amine-tetrahydrothiophenes with a Quaternary Stereocenter via Nickel(II)/Trisoxazoline-Catalyzed Sulfa-Michael/Aldol Cascade Reaction: Divergent Access to Chiral Thionucleosides, Category: benzoxazole, the publication is Organic Letters (2021), 23(1), 81-86, database is CAplus and MEDLINE.

A generally useful Ni(II)/trisoxazoline-catalyzed asym. sulfa-Michael/Aldol cascade reaction is introduced to access chiral 3-amine-tetrahydrothiophene derivatives containing a quaternary stereocenter (32 examples, up to 93% yield, > 20:1 dr and 92% ee). Moreover, the novel strategy offers an efficient and convenient approach to construct chiral thionucleoside analogs.

Organic Letters published new progress about 1239015-11-2. 1239015-11-2 belongs to benzoxazole, auxiliary class TOX Ligands, name is (3aS,3a’S,3a”S,8aR,8a’R,8a”R)-2,2′,2″-(Propane-1,2,2-triyl)tris(8,8a-dihydro-3aH-indeno[1,2-d]oxazole), and the molecular formula is C33H29N3O3, Category: benzoxazole.

Referemce:
https://en.wikipedia.org/wiki/Benzoxazole,
Benzoxazole | C7H5NO – PubChem

Ma, Xueji’s team published research in Organic & Biomolecular Chemistry in 20 | CAS: 1207294-92-5

Organic & Biomolecular Chemistry published new progress about 1207294-92-5. 1207294-92-5 belongs to benzoxazole, auxiliary class Achiral NHCs Ligands, name is 5,7-Di-tert-butyl-3-phenylbenzo[d]oxazol-3-ium tetrafluoroborate, and the molecular formula is C21H26BF4NO, Recommanded Product: 5,7-Di-tert-butyl-3-phenylbenzo[d]oxazol-3-ium tetrafluoroborate.

Ma, Xueji published the artcileNHC-alcohol adduct-mediated photocatalytic deoxygenation for the synthesis of 6-phenanthridine derivatives, Recommanded Product: 5,7-Di-tert-butyl-3-phenylbenzo[d]oxazol-3-ium tetrafluoroborate, the publication is Organic & Biomolecular Chemistry (2022), 20(27), 5393-5396, database is CAplus and MEDLINE.

NHC-alc. adduct-mediated deoxygenation of alcs. ROH (R = t-Bu, cyclopentyl, N-bocpiperidin-4-yl, etc.) under photocatalytic conditions is described. This process provides various alkyl radicals, which can react with 2-isocyanobiaryls I (R1 = H, Me, F; R2 = H, Cl; R3 = H, MeO, CF3; R4 = H, F, Me, MeO; R5 = H, MeO, CF3; R6 = H, Me, F) to afford 6-substituted phenanthridine derivatives II in moderate to good yields. This method offered the first example of directly using alcs. as radical sources for 6-phenanthridine synthesis.

Organic & Biomolecular Chemistry published new progress about 1207294-92-5. 1207294-92-5 belongs to benzoxazole, auxiliary class Achiral NHCs Ligands, name is 5,7-Di-tert-butyl-3-phenylbenzo[d]oxazol-3-ium tetrafluoroborate, and the molecular formula is C21H26BF4NO, Recommanded Product: 5,7-Di-tert-butyl-3-phenylbenzo[d]oxazol-3-ium tetrafluoroborate.

Referemce:
https://en.wikipedia.org/wiki/Benzoxazole,
Benzoxazole | C7H5NO – PubChem

Zhou, You-Yun’s team published research in Journal of the American Chemical Society in 134 | CAS: 1239015-11-2

Journal of the American Chemical Society published new progress about 1239015-11-2. 1239015-11-2 belongs to benzoxazole, auxiliary class TOX Ligands, name is (3aS,3a’S,3a”S,8aR,8a’R,8a”R)-2,2′,2″-(Propane-1,2,2-triyl)tris(8,8a-dihydro-3aH-indeno[1,2-d]oxazole), and the molecular formula is C17H19N3O7S, Category: benzoxazole.

Zhou, You-Yun published the artcileSide-Arm-Promoted Highly Enantioselective Ring-Opening Reactions and Kinetic Resolution of Donor-Acceptor Cyclopropanes with Amines, Category: benzoxazole, the publication is Journal of the American Chemical Society (2012), 134(22), 9066-9069, database is CAplus and MEDLINE.

In the presence of a nonracemic tridentate trisoxazoline ligand I and nickel(II) perchlorate, bis(neopentyl) cyclopropanedicarboxylates II [R = Me3CCH2; R1 = Ph, 4-ClC6H4, 4-BrC6H4, 3,4-Cl2C6H3, 4-O2NC6H4, 4-MeC6H4, 3-MeC6H4, 4-MeOC6H4, 2-MeOC6H4, 3,4-(MeO)2C6H3, 2-thienyl, (E)-PhCH:CH, H2C:CH, 2-furyl] underwent enantioselective ring-opening reactions with amines R2R3NH [R2 = (E)-Me3CO2CCH:CHCH2, PhCH2, TBDMSOCH2CH2, EtO2CCH2, H2C:CHCH2, (MeO)2CHCH2; R3 = PhCH2, 4-MeOC6H4CH2, Ph; TBDMS = tert-butyldimethylsilyl] to give nonracemic γ-aminodiesters (R)-R1CH(NR2R3)CH2CH(CO2R)2 [R = Me3CCH2; R1 = Ph, 4-ClC6H4, 4-BrC6H4, 3,4-Cl2C6H3, 4-O2NC6H4, 4-MeC6H4, 3-MeC6H4, 4-MeOC6H4, 2-MeOC6H4, 3,4-(MeO)2C6H3, 2-thienyl, (E)-PhCH:CH, H2C:CH, 2-furyl; R2 = (E)-Me3CO2CCH:CHCH2, PhCH2, TBDMSOCH2CH2, EtO2CCH2, H2C:CHCH2, (MeO)2CHCH2; R3 = PhCH2, 4-MeOC6H4CH2, Ph] in 59-99% yields and in 80-98% ee. In the presence of I and nickel(II) perchlorate, reaction of II (R = Me3CCH2; R1 = Ph, 4-ClC6H4, 4-BrC6H4, 4-MeC6H4, 3-MeC6H4) underwent kinetic resolution with BnNHR2 [R2 = (E)-Me3CO2CCH:CHCH2, PhCH2, (MeO)2CHCH2] to give nonracemic II in 39-46% yields and in 90-97% ee. The structure of the nickel(II) perchlorate complex with an unsym. analog of I was determined by X-ray crystallog.

Journal of the American Chemical Society published new progress about 1239015-11-2. 1239015-11-2 belongs to benzoxazole, auxiliary class TOX Ligands, name is (3aS,3a’S,3a”S,8aR,8a’R,8a”R)-2,2′,2″-(Propane-1,2,2-triyl)tris(8,8a-dihydro-3aH-indeno[1,2-d]oxazole), and the molecular formula is C17H19N3O7S, Category: benzoxazole.

Referemce:
https://en.wikipedia.org/wiki/Benzoxazole,
Benzoxazole | C7H5NO – PubChem