(S-Methylsulfonimidoyl)benzene (BD302898) is a building block containing a sulfoximine group. Several CDK and ATR inhibitors have exemplified the utilization of the NH sulfoximine group as abioisostere for a sulfonamide group to overcome the main project hurdles of aqueous solubility, sulfonamide-mediated off-target activity and IP. Moreover, its NH group could be expediently further functionalized through Buchwald-Hartwig coupling reaction and multifarious nucleophilic reactions.. Recommended Products is: 83730-53-4 and 1621962-30-8.
A Pd(II)-catalyzed direct arylation of NH-sulfoximines and sulfonamides with arylhydrazine hydrochlorides was herein demonstrated without participation of any organic ligands under mild conditions. The oxidative methodol. afforded a smooth routine toward N-aryl sulfoximines and sulfonamides with high efficiency (up to 93% yields) and broad functional groups tolerance (up to 40 examples) through a denitrogenative pathway. The protocol was proposed to take place through the free radical pathway based on the results of control reactions and literature explorations.
Palladium-catalyzed denitrogenative arylation of sulfoximines and sulfonamides with arylhydrazines under mild conditions. Recommended basis is Sulfoximine, Bioisosteric. Products is: https://www.ambeed.com/products/50578-18-2.html, 145026-07-9
Referemce:
Benzoxazole – Wikipedia,
Benzoxazole | C7H5NO – PubChem