1-Iminotetrahydrothiophene 1-oxide (BD00963737) is a building block containing a sulfoximine group. Several CDK and ATR inhibitors have exemplified the utilization of the NH sulfoximine group as abioisostere for a sulfonamide group to overcome the main project hurdles of aqueous solubility, sulfonamide-mediated off-target activity and IP. Moreover, its NH group could be expediently further functionalized through Buchwald-Hartwig coupling reaction and multifarious nucleophilic reactions.. Recommended Products is: 4381-25-3 and 83730-53-4.
A general protocol for the N-thioetherification of NH-sulfoximines has been developed. Catalyzed by [Cu(DMAP)4I]I, N-sulfenyl sulfoximines, e.g I, were synthesized by a one-pot cascade reaction with com. available thiophenols as the sulfur source at room temperature The protocol has mild reaction conditions, is operationally simple and affords the corresponding products with good yields and excellent tolerance of functional groups.
A One-Pot Cascade Reaction by Combining NH-Sulfoximines with Thiophenols Under Mild Conditions. Recommended basis is Sulfoximine, Bioisosteric. Products is: https://www.ambeed.com/products/1621962-30-8.html, 145026-07-9
Referemce:
Benzoxazole – Wikipedia,
Benzoxazole | C7H5NO – PubChem