In an article, author is Zhao, Bo-Bo, once mentioned the application of 372-38-3, Name is 1,3,5-Trifluorobenzene, molecular formula is C6H3F3, molecular weight is 132.0832, MDL number is MFCD00000333, category is benzoxazole. Now introduce a scientific discovery about this category, Category: benzoxazole.
K313, a novel benzoxazole derivative, exhibits anti-inflammatory properties via inhibiting GSK3 activity in LPS-induced RAW264.7 macrophages
Benzoxazole and its derivatives have been widely studied in recent years due to their various biological properties. A previous study has demonstrated that K313 (1H-indole-2,3-dione 3-(1,3-benzoxazol-2-ylhydrazone)), a novel benzoxazole derivative, inhibits T cell proliferation to yield immunosuppressive effects. However, there are no related reports about its anti-inflammatory effects. In the present study, we investigated the anti-inflammatory properties and the underlying molecular mechanism of K313 in lipopolysaccharide (LPS)-induced RAW264.7 macrophages. K313 dose-dependently (5, 10, and 20M) inhibited LPS-stimulated nitric oxide (NO), interleukin (IL)-6, tumor necrosis factor (TNF)-, and 3-nitrotyrosine (3-NT) production and significantly decreased the gene transcription levels of inducible nitric oxide (iNOS), IL-6, and TNF-. In addition, the results showed that the inflammatory cytokines suppressed by K313 were not regulated by p65 NF-B, ERK1/2, AKT, or p38 MAPK. Instead, K313 increased phosphorylation of glycogen synthase kinase-3 beta (GSK-3) (Ser9) resulting in GSK-3 deactivation. Moreover, in LPS-stimulated RAW264.7 macrophages, K313 and lithium chloride (LiCl) had a synergistic effect on the anti-inflammatory response. These results indicated that K313 exhibited anti-inflammatory properties and revealed the potential mechanism. K313 can increase GSK-3 (Ser9) phosphorylation to decrease GSK-3 activation in LPS-induced RAW264.7 macrophages.
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Reference:
Benzoxazole – Wikipedia,
,Benzoxazole | C7H5NO – PubChem