(S-Methylsulfonimidoyl)benzene (BD302898) is a building block containing a sulfoximine group. Several CDK and ATR inhibitors have exemplified the utilization of the NH sulfoximine group as abioisostere for a sulfonamide group to overcome the main project hurdles of aqueous solubility, sulfonamide-mediated off-target activity and IP. Moreover, its NH group could be expediently further functionalized through Buchwald-Hartwig coupling reaction and multifarious nucleophilic reactions.. Recommended Products is: 83730-53-4 and 1621962-30-8.
The synthesis of chiral benzothiazepine-1-oxides with a seven-membered ring via achiral Ru(II)-catalyzed asym. [4 + 3] annulation of sulfoximines with ¦Á,¦Â-unsaturated ketones assisted by chiral carboxylic acid (CCA) was reported. A broad range of chiral benzothiazepine-1-oxides bearing various functional groups was prepared in up to 90% yield with up to >99% ee, expanding the chem. space of chiral sulfoximines. Notably, the oxidative cleavage of the double bonds in the products gave chiral N-benzoyl sulfoximines with a C-S chiral axis.
Ru(II)/Chiral Carboxylic Acid-Catalyzed Asymmetric [4 + 3] Annulation of Sulfoximines with ¦Á,¦Â-Unsaturated Ketones. Recommended basis is Sulfoximine, Bioisosteric. Products is: https://www.ambeed.com/products/50578-18-2.html, 145026-07-9
Referemce:
Benzoxazole – Wikipedia,
Benzoxazole | C7H5NO – PubChem