Palladium-catalyzed ortho-nitration of 2-arylbenzoxazoles was written by Qiao, Hui-Jie;Yang, Fan;Wang, Shi-Wei;Leng, Yu-Ting;Wu, Yang-Jie. And the article was included in Tetrahedron in 2015.Computed Properties of C13H8BrNO This article mentions the following:
An efficient and general protocol for palladium-catalyzed chelation-assisted ortho-nitration of 2-arylbenzoxazoles has been developed. This nitration exhibits high regioselectivity for the substrates, and the reaction could tolerate many functional groups such as F, Cl, Br, CH3, CH3O, affording ortho-nitration products in moderate to good yields. Moreover, some 2-arylbenzoxazole heterocyclic analogs proceed well under this catalytic system. Further studies have been performed to obtain insight into the mechanism. In the experiment, the researchers used many compounds, for example, 2-(3-Bromophenyl)benzo[d]oxazole (cas: 99586-31-9Computed Properties of C13H8BrNO).
2-(3-Bromophenyl)benzo[d]oxazole (cas: 99586-31-9) belongs to benzoxazole derivatives. Although benzoxazole itself is of little practical value, many derivatives of benzoxazoles are commercially important. A number of marketed drugs are available having benzoxazole as core active moiety like, nonsteroidal anti-inflammatory drug (NSAID)—flunoxaprofen, benoxaprofen, antibiotic—calcimycin.Computed Properties of C13H8BrNO
Referemce:
Benzoxazole – Wikipedia,
Benzoxazole | C7H5NO – PubChem