So far, in addition to halogen atoms, other non-metallic atoms can become part of the aromatic heterocycle, and the target ring system is still aromatic.Rahman, Akib Bin; Okamoto, Hirokazu; Miyazawa, Yuya; Aoki, Shin researched the compound: 1,4,7,10,13-Pentaoxa-16-azacyclooctadecane( cas:33941-15-0 ).COA of Formula: C12H25NO5.They published the article 《Design and Synthesis of Supramolecular Phosphatases Formed from a Bis(Zn2+-Cyclen) Complex, Barbital-Crown-K+ Conjugate and Cu2+ for the Catalytic Hydrolysis of Phosphate Monoester》 about this compound( cas:33941-15-0 ) in European Journal of Inorganic Chemistry. Keywords: alk zinc copper cyclen barbital crown complex preparation; hydrolysis catalyst alk zinc copper cyclen barbital crown complex; DFT alk zinc copper cyclen barbital crown complex. We’ll tell you more about this compound (cas:33941-15-0).
The development of artificial mimics of natural enzymes such as hydrolases and phosphatases is one of the great challenges in bioorganic and bioinorganic chem. and related sciences. Supramol. strategies are one of the useful methods to construct artificial catalysts as mimics of natural enzymes and to understand their reaction mechanisms. Herein, the authors report on the formation of amphiphilic supramol. phosphatases by the 2 : 2 : 2 self-assembly of a bis(Zn2+-cyclen) complex (cyclen = 1,4,7,10-teraazacyclododecane) containing a 2,2′-bipyridyl (bpy) linker and one long alkyl chain (Zn2L3), 5,5-diethylbarbituric acid (Bar) derivative functionalized with 1-aza-18-crown-6 ether and Cu2+ in a two-phase solvent system (CHCl3/H2O). The authors hypothesized that crown ether moiety of the Bar-crown ether conjugate would form complexes with alk. ions and other metal ions such as Li+, Na+, K+, Rb+, Mg2+ and La3+ in organic phase to mimic the Mg2+ found as the third metal ion in the active site of alk. phosphatase (AP). The 2 : 2 : 2 : 4 complexes of Zn2L3, a Bar block equipped with the 18-crown-6 ether, Cu2+ and alk. metal are constructed in a two-phase solvent system. The resulting complexes have a higher hydrolysis activity for mono(4-nitrophenyl)phosphate (MNP) in the presence of K+ than that in the presence of Li+, Na+, Rb+, Mg2+ and La3+ and a greater hydrolysis activity than the authors′ previous supermols. having no crown ether part, suggesting that crown ether-K+ complex located in close proximity to the Cu2(μ-OH)2 core contributes to the acceleration of the MNP hydrolysis.
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Reference:
Benzoxazole – Wikipedia,
Benzoxazole | C7H5NO – PubChem