Efficient synthesis of 2-substituted benzoxazoles via Beckmann rearrangement of 2-hydroxyaryl ketoximes using diethyl chlorophosphate was written by Sardarian, A. R.;Shahsavari-Fard, Z.. And the article was included in Synlett in 2008.Recommanded Product: 2,5-Dimethylbenzoxazole This article mentions the following:
An efficient method for the synthesis of 2-substituted benzoxazoles, e.g., I has been developed using di-Et chlorophosphate. 2-Hydroxyaryl ketoximes, e.g., II are efficiently converted to benzoxazoles by heating in the presence of di-Et chlorophosphate via a Beckmann rearrangement of the corresponding ketoxime in excellent yields. This method avoids the use of strong acids, harsh conditions, and long reaction times. In the experiment, the researchers used many compounds, for example, 2,5-Dimethylbenzoxazole (cas: 5676-58-4Recommanded Product: 2,5-Dimethylbenzoxazole).
2,5-Dimethylbenzoxazole (cas: 5676-58-4) belongs to benzoxazole derivatives. Benzoxazole nucleus is one of the most important heterocyclic compounds exhibiting remarkable pharmacological activities. Benzoxazoles are prominent in medicinal chemistry due to their wide spectrum of pharmacological activities such as antiparkinson, inhibition of hepatitis C virus, 5-HT3 antagonistic effect.Recommanded Product: 2,5-Dimethylbenzoxazole
Referemce:
Benzoxazole – Wikipedia,
Benzoxazole | C7H5NO – PubChem