3889-13-2, In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 5-Nitro-2,3-dihydro-1,3-benzoxazol-2-one, cas is 3889-13-2,the benzoxazole compound, it is a common compound, a new synthetic route is introduced below.
Step 2. To a solution of 5-nitrobenzo[d]oxazol-2(3H)-one (1.67 g, 9.27 mmol) in MeOH (50 mL) and DCM (50 mL) was added 10% palladium/C (0.247 g, 0.232 mmol). The reaction mixture was placed on a Parr shaker under H2 (30 psi) overnight. The suspension was filtered and evaporated in vacuo to afford 5-aminobenzo[d]oxazol-2(3H)-one (1.35 g) as a white solid. NMR (500 MHZ, DMSO-de) delta 11.20 (br. s., 1H), 6.91 (d, J=8.5 Hz, 1H), 6.33 (d, J=2.0 Hz, 1H), 6.25 (dd, J=8.4, 2.1 Hz, 1H), 5.23 (br. s., 2H).
The chemical industry reduces the impact on the environment during synthesis,3889-13-2,5-Nitro-2,3-dihydro-1,3-benzoxazol-2-one,I believe this compound will play a more active role in future production and life.
Reference：
Patent; VIIV HEALTHCARE (No.5) LIMITED; BENDER, John A.; LOPEZ, Omar D.; NGUYEN, Van N.; YANG, Zhong; WANG, Alan Xiangdong; WANG, Gan; MEANWELL, Nicholas A.; BENO, Brett R.; FRIDELL, Robert A.; BELEMA, Makonen; THANGATHIRUPATHY, Srinivasan; (350 pag.)WO2016/172425; (2016); A1;,
Benzoxazole – Wikipedia
Benzoxazole | C7H5NO – PubChem