5-Nitro-2,3-dihydro-1,3-benzoxazol-2-one, cas is 3889-13-2, it is a common heterocyclic compound, the benzoxazole compound, its synthesis route is as follows.,3889-13-2
General procedure: To a stirred suspension of benzo [d]oxazol-2(3H)-ones, anhydrousK2CO3 (1.2 mmol) was added in the dry DMF solvent for20 min at 60 C. Then chloroacetylated 3a-3e (1.3 mmol) and TBAI(0.1 mmol) were added simultaneously. The reaction was stirredand heated for 5 h. After completion, the mixture was extractedwith DCM/H2O three times. The combined organic layers werewashed with brine, dried over anhydrous Na2SO4, filtered and concentrated under reduced pressure. The crude product was purifiedby silica gel column chromatography eluting with DCM/Methanol (20:1e10:1) to afford compounds D01-D08.
3889-13-2 is used more and more widely, we look forward to future research findings about 5-Nitro-2,3-dihydro-1,3-benzoxazol-2-one
Reference£º
Article; Yang, Lixin; Liu, Yongqing; Fan, Minghua; Zhu, Guiwang; Jin, Hongwei; Liang, Jing; Liu, Zhenming; Huang, Zhuo; Zhang, Liangren; European Journal of Medicinal Chemistry; vol. 182; (2019);,
Benzoxazole – Wikipedia
Benzoxazole | C7H5NO – PubChem