2-Benzoxazolinone, cas is 59-49-4, it is a common heterocyclic compound, the benzoxazole compound, its synthesis route is as follows.,59-49-4
2j: 3-(3-Chloro-propyl)-3H-benzoxazol-2-one Sodium hydride (60% in oil dispersion) (155 mmol) was washed with diethyl ether under an argon atmosphere, then suspended in DMF (75 mL). 3H-Benzoxazol-2-one (148 mmol) was dissolved in DMF (150 mL) and added drop wise to the slurry. After stirring for ca. 30 min. the mixture was homogenous and was then cooled to -5 C on an acetone-ice bath. 1-Bromo- 3-chloropropane (296 mmol) was dissolved in DMF (50 mL) and added drop wise to the cold solution. The reaction mixture was allowed to come to room temperature and stirring was continued for 18h. Poured into H2O, the aqueous phase was extracted x3 with ethyl acetate.The combined organic fractions were washed x2 with NH4Cl (aq., sat.) dried on MgSO4 and the solvent was removed by evaporation to yield an oil which solidified on standing. The obtained solid was washed with diethyl ether and dried in vacuo. The product was udes without further purification.Yield = 54%1H NMR (D6-DMSO): 2.16 (qui, 2H); 3.71 (t, 2H); 3.96 (t, 2H); 7.14 (t, IH); 7.24 (t, IH);7.29-7.36 (2H).
With the rapid development of chemical substances, we look forward to future research findings about 2-Benzoxazolinone
Reference£º
Patent; H. LUNDBECK A/S; WO2009/106534; (2009); A1;,
Benzoxazole – Wikipedia
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