A rapid and efficient microwave-assisted synthesis of 2-arylbenzoxazoles by using 1,3-dibromo-5,5-dimethylhydantoin (DBH) under solvent-free condition was written by Shinde, Kailas W.;Keche, Ashish P.. And the article was included in Journal of Chemical and Pharmaceutical Research in 2016.Application In Synthesis of 2-(3-Bromophenyl)benzo[d]oxazole This article mentions the following:
A simple, rapid and efficient procedure for the synthesis of 2-arylbenzoxazole derivatives I [R= H, Me, MeO, Cl; R1 = 3-Me, 3-MeO, 3-NO2-4-Cl, etc.] was developed from 2-aminophenol and arylaldehydes by using 1,3-dibromo-5,5-dimethylhydantoin (DBH) in moderate to good yields under solvent-free microwave irradiation The remarkable efficiency of DBH under solvent free microwave irradiation led many advantages like, the use of non-corrosive, inexpensive reagents, simple workup procedure, in addition to the eco-friendly green chem. economical and environmental impacts. In the experiment, the researchers used many compounds, for example, 2-(3-Bromophenyl)benzo[d]oxazole (cas: 99586-31-9Application In Synthesis of 2-(3-Bromophenyl)benzo[d]oxazole).
2-(3-Bromophenyl)benzo[d]oxazole (cas: 99586-31-9) belongs to benzoxazole derivatives. Benzoxazole nucleus is one of the most important heterocyclic compounds exhibiting remarkable pharmacological activities. A number of marketed drugs are available having benzoxazole as core active moiety like, nonsteroidal anti-inflammatory drug (NSAID)—flunoxaprofen, benoxaprofen, antibiotic—calcimycin.Application In Synthesis of 2-(3-Bromophenyl)benzo[d]oxazole
Referemce:
Benzoxazole – Wikipedia,
Benzoxazole | C7H5NO – PubChem