With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.128156-54-7,Methyl benzo[d]oxazole-4-carboxylate,as a common compound, the synthetic route is as follows.
Example compound obtained in 56-2 (500 mg, 2.82 mmol) in tetrahydrofuran (10 ml), and ethanol (10 ml) solution of calcium chloride (626 mg, 5.64 mmol) was added dissolved at 0 . Sodium borohydride (427 mg, 11.29 mmol) was added and the mixture was stirred for 2 hours at room temperature. After completion of the reaction, 1mol / l hydrochloric acid was added, and the mixture was extracted with ethyl acetate. Dried over anhydrous sodium sulfate, filtered, and concentrated under reduced pressure. The residue was purified by silica gel column chromatography (hexane / ethyl acetate) to give the title compound (154 mg, 37%)., 128156-54-7
As the paragraph descriping shows that 128156-54-7 is playing an increasingly important role.
Reference£º
Patent; Yakult Honsha Co., Ltd.; University of Occupational and Environmental Health; Ono, Masahiro; Kobayashi, Tsuneyuki; Yamazaki, Ryuta; Haibara, Hirotake; Nishiyama, Yukiko; Hokkyo, Atsuko; Nishiyama, Hiroyuki; Kurita, Akinobu; Matsuzaki, Ken; Kono, Kimitoshi; Izumi, Hiroto; (215 pag.)JP2016/124812; (2016); A;,
Benzoxazole – Wikipedia
Benzoxazole | C7H5NO – PubChem