With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.136992-95-5,Benzo[d]oxazol-7-amine,as a common compound, the synthetic route is as follows.
General procedure: 6-Bromo-4-chloroquinoline (1.0 equiv.) and 3,4,5-trimethoxyaniline (1.1 equiv.) were suspended in ethanol (10 mL) and refluxed for 18 h. The crude mixture was purified by flash chromatography using EtOAc:hexane followed by 1-5% methanol in EtOAc, solvent was removed under reduced pressure to afford the desired product (1, 8-11, 13-31, and 33-43)., 136992-95-5
As the paragraph descriping shows that 136992-95-5 is playing an increasingly important role.
Reference£º
Article; Asquith, Christopher R.M.; Bennett, James M.; Su, Lianyong; Laitinen, Tuomo; Elkins, Jonathan M.; Pickett, Julie E.; Wells, Carrow I.; Li, Zengbiao; Willson, Timothy M.; Zuercher, William J.; Molecules; vol. 24; 22; (2019);,
Benzoxazole – Wikipedia
Benzoxazole | C7H5NO – PubChem