With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.19932-85-5,6-Bromobenzo[d]oxazol-2(3H)-one,as a common compound, the synthetic route is as follows.
General procedure: The crude product above (2.0mmol) was dissolved in DMF (20mL). The corresponding benzo[d]oxazol-2(3H)-one (2.4mmol) and Cs2CO3 (782mg, 2.4mmol) was added to the solution. The reaction mixture was stirred at 50C for 5h and then cooled to room temperature. The mixture was diluted with water (40mL) and then was extracted with ethyl acetate (20mL¡Á3). The combined organic layer was washed by saturated sodium chloride solution for three times, dried over anhydrous Na2SO4 and concentrated under reduced pressure. The residue was purified by silica gel chromatography to afford 11. White solid (27%, 4 steps). 1H NMR (300MHz, CDCl3) delta 8.73 (d, J=5.1Hz, 1H), 8.20 (s, 1H), 7.81 (d, J=8.9Hz, 1H), 7.55 (d, J=8.7Hz, 1H), 7.41 (s, 1H), 7.39 (s, 1H), 7.06 (d, J=8.8Hz, 1H), 6.72 (d, J=5.3Hz, 1H), 4.52 (t, J=4.9Hz, 2H), 4.39 (d, J=5.2Hz, 2H). MS (ESI): 463.1 [M+H]+. Purity: >95%, 19932-85-5
As the paragraph descriping shows that 19932-85-5 is playing an increasingly important role.
Reference£º
Article; Lu, Dong; Shen, Aijun; Liu, Yang; Peng, Xia; Xing, Weiqiang; Ai, Jing; Geng, Meiyu; Hu, Youhong; European Journal of Medicinal Chemistry; vol. 115; (2016); p. 191 – 200;,
Benzoxazole – Wikipedia
Benzoxazole | C7H5NO – PubChem