With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.59-49-4,2-Benzoxazolinone,as a common compound, the synthetic route is as follows.
General procedure: Intermediates 19-26 were prepared following literature procedures, with slight modifications [50]. A solution of 10-14 (6.6mmol) in acetone (20mL) was mixed with K2CO3 (10mmol) and stirred at room temperature for 10min. After addition of the appropriate 1-bromo-omega-chloroalkane or 1,omega-dibromoalkane (7.3mmol), the mixture was stirred for further 24h. Inorganic materials was removed by filtration, then the solvent was removed in vacuum to obtain a residue which was used without any further purification for the next step. For analytical purpose, crude 23-26 were purified by flash chromatography or by recrystallization.
As the paragraph descriping shows that 59-49-4 is playing an increasingly important role.
Reference£º
Article; Salerno, Loredana; Pittala, Valeria; Romeo, Giuseppe; Modica, Maria N.; Marrazzo, Agostino; Siracusa, Maria A.; Sorrenti, Valeria; Di Giacomo, Claudia; Vanella, Luca; Parayath, Neha N.; Greish, Khaled; European Journal of Medicinal Chemistry; vol. 96; (2015); p. 162 – 172;,
Benzoxazole – Wikipedia
Benzoxazole | C7H5NO – PubChem