With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.59-49-4,2-Benzoxazolinone,as a common compound, the synthetic route is as follows.
70% Nitric acid (50?mL, 0.80?mol) was cooled to 0?C and 3H-1,3-benzoxazol-2-one (5.00?g, 37?mmol) was added. The reaction mixture was stirred at rt for 4?h and then poured in ice.The resulting precipitate was collected by filtration, washed with water and dried to give a pink solid (5.80?g, 32.5?mmol, 87%). Mp?>?250?C. 1H NMR (300?MHz, DMSOd6): delta 12.41 (s, 1H), 8.20 (d, J?=?2.2?Hz, 1H), 8.13 (dd, J?=?8.6?Hz, J?=?2.2?Hz, 1H), 7.28 (d, J?=?8.6?Hz, 1H).13C NMR (300?MHz, DMSOd6): delta 154.7, 143.2, 142.5, 137.2, 121.2, 109.8, 105.8. LCMS m/z calc for [M?-?H]+: 179.0, found: 179.0., 59-49-4
As the paragraph descriping shows that 59-49-4 is playing an increasingly important role.
Reference£º
Article; Gay, Marion; Evrard, Caroline; Descamps, Florian; Carato, Pascal; Renault, Nicolas; Coevoet, Mathilde; Eddarkaoui, Sabiha; Baud, Catherine; Larchanche, Paul-Emmanuel; Buee, Luc; El Bakali, Jamal; Vingtdeux, Valerie; Sergeant, Nicolas; Melnyk, Patricia; European Journal of Medicinal Chemistry; vol. 159; (2018); p. 104 – 125;,
Benzoxazole – Wikipedia
Benzoxazole | C7H5NO – PubChem