Copper-catalyzed an efficient synthesis, characterization of 2-substituted benzoxazoles, 2-substituted benzothiazoles derivatives and their anti-fungal activity was written by Sirgamalla, Rambabu;Kommakula, Ashok;Konduru, Sumalatha;Ponakanti, Ravindar;Devaram, J.;Boda, Sakram. And the article was included in Chemical Data Collections in 2020.Formula: C13H8BrNO This article mentions the following:
An efficient synthesis of 2-substituted benzoxazoles, (I) (R = H, Me, Cl, NO2; R1 = 3-F, 2-OH, 4-Me, 4-OMe, etc.) and 2-substituted benzothiazole (I) (R = H, Me, Cl, NO2; R1 = 4-F, 4-Me, 4-OMe, 4-NO2, etc.) from condensation of 2-aminophenol, and 2-aminothiophenol react with various aldehydes in Cu2O in the presence of DMSO oxidant system has been developed. This reaction is operationally simple, proceeds with copper catalysts, tolerates a wide range of functionalities, and provides elemental anal. (C, H, N) providing desired products in good to excellent yields. All the synthesized compounds were screened for anti-fungal activity. Among all the compounds shows good activity I (R = H, R1= 4-OMe; R = Me, R1= 4-OMe; R = Cl, R1= 4-OMe; R = Cl, R1= 4-OH), (III) and (II) (R = H, R1= 4-F; R = H, R1= 4-OMe) shows equal to reference drug. In the experiment, the researchers used many compounds, for example, 2-(3-Bromophenyl)benzo[d]oxazole (cas: 99586-31-9Formula: C13H8BrNO).
2-(3-Bromophenyl)benzo[d]oxazole (cas: 99586-31-9) belongs to benzoxazole derivatives. Although benzoxazole itself is of little practical value, many derivatives of benzoxazoles are commercially important. Due to its versatile biological properties, benzoxazole has been incorporated as an essential pharmacophore and substructure in many medicinal compounds.Formula: C13H8BrNO
Referemce:
Benzoxazole – Wikipedia,
Benzoxazole | C7H5NO – PubChem