Chemistry is the experimental and theoretical study of materials on their properties at both the macroscopic and microscopic levels. 352-34-1, Name is 1-Fluoro-4-iodobenzene, molecular formula is C6H4FI. In an article, author is Abdel-Gawad, Sherif A.,once mentioned of 352-34-1, Recommanded Product: 352-34-1.
Validated High Performance Liquid Chromatographic Quantification of Pamidronate in Bulk and Dosage Form
Aims: The studied drug is lacking the presence of chromophore so a reaction with NBD-Cl is optimized to facilitate its chromatographic detection, so the main aim of the work is to quantify pamidronate in a sensitive and accurate way either in bulk or dosage forms. Methodology: The quantification of this group of drugs is a challenging task as they lack the presence of chromophore groups in their structure. The proposed method depends on the chromatographic quantification of the studied drug after its derivatization via its reaction with 4-Chloro-7-nitro-2,1,3-benzoxazole and the product is separated on ODS C18 column (5 mu m, 15 cm x 5 mm, i.d.) as a stationary phase and methanol : water (8:2, v/v) as a mobile phase. The flow rate was 1 ml/min. Results: The studied drug can be determined in the range of 900 – 3000 ng/mL after optimizing the assay conditions to get optimum stationary – mobile phases match. Method validation is performed according to USP-guidelines and different validation parameters like, linearity, accuracy, precision and robustness are calculated and found to be excellent. Conclusion: The proposed method is accurate, sensitive and can be applied for the routine analysis of pamidronate in quality control laboratories.
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Reference:
Benzoxazole – Wikipedia,
,Benzoxazole | C7H5NO – PubChem