Some scientific research about 2-(Trifluoromethyl)benzo[d]oxazole

I hope this article can help some friends in scientific research. I am very proud of our efforts over the past few months and hope to 2008-04-0, help many people in the next few years.COA of Formula: C8H4F3NO

In heterogeneous catalysis, the catalyst is in a different phase from the reactants. COA of Formula: C8H4F3NO, At least one of the reactants interacts with the solid surface in a physical process called adsorption in such a way. 2008-04-0, name is 2-(Trifluoromethyl)benzo[d]oxazole. In an article£¬Which mentioned a new discovery about 2008-04-0

Mechanism of formation of serine beta-lactones by Mitsunobu cyclization: synthesis and use of L-serine stereospecifically labelled with deuterium at C-3

The ring closure of N-benzyloxycarbonyl-L-serine (1) under Mitsunobu conditions (Ph3P, dimethyl azodicarboxylate, -78 deg C) to give the corresponding beta-lactone (2) is shown by deuterium and oxygen-18 labelling studies to proceed by hydroxy group activation, in contrast to analogous cyclizations of more hindered beta-hydroxy acids, which usually occur by carboxy group activation.Samples of 1 stereospecifically labelled with deuterium at C-3 were prepared by hydrogenation of (Z)-2-acetamido-3-methoxyacrylic acid (9) with deuterium, followed by selective Acylase I deacetylation of the 2S isomer, removal of the protecting groups, and N-acylation of the resulting L-serine with benzyl chloroformate.Mitsunobu cyclizations of this 3R deuterated N-acyl serine, of the analog lg, and of the derivative 1f show that lactonization occurs with inversion of configuration at C-3, loss of the hydroxy oxygen, and retention of the carboxy oxygens.Similar labelling experiments demonstrate that aqueous sodium hydroxide opens the beta-lactone ring by exclusive attack at the carbonyl to regenerate 1, whereas acidic hydrolysis proceeds primarily by attack of water at the C-3 methylene group of 2.This information allows interconversion of L-serines that are stereospecifically labelled at C-3 with hydrogen isotopes and affords access to other labelled beta-substituted alanines.

I hope this article can help some friends in scientific research. I am very proud of our efforts over the past few months and hope to 2008-04-0, help many people in the next few years.COA of Formula: C8H4F3NO

Reference£º
Benzoxazole – Wikipedia,
Benzoxazole | C7H5NO – PubChem